Prevention of Dementia in elderly Indians (SMRUTHI-INDIA)
Not Applicable
- Registration Number
- CTRI/2024/01/061172
- Lead Sponsor
- Department of Health Research,ICMR,MOHFW, ICMR
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
1. Age more than or equal to 55 years
2. Permanent resident of the defined area
3. CAIDE (Cardiovascular Risk Factors Aging and Dementia) Risk Score of 6 points or higher
4. Absence of Dementia or MCI (DSM 5 criteria for major Neurocognitive Decline) after Neuropsychological evaluation
5. Consenting to participate and complete all study related activities for 5 years
Exclusion Criteria
1. Established Dementia
2. Disabling stroke or structural brain abnormality
3. Vision, hearing or communication impairment affecting NP testing
4. Psychiatric illness- major depressive disorder, psychosis
5. Significant medical illness like malignancy, end stage renal disease, decompensated liver disease
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Incidence of all cause probable dementia or mild cognitive impairmentTimepoint: 5 years
- Secondary Outcome Measures
Name Time Method Change in composite and domain Z scoresTimepoint: 5 years;Change in LIBRA IndexTimepoint: 5 years;Composite outcome of stroke and MITimepoint: 5 YEARS;Composite outcome of stroke, MI, MCI, DementiaTimepoint: 5 years;Incidence of mild cognitive impairmentTimepoint: 5 years;MortalityTimepoint: 5 years;time to first occurrence of diagnosis of dementiaTimepoint: 5 years;time to first occurrence of diagnosis of MCITimepoint: 5 YEARS