The predictive value of peripheral muscle ultrasound in the diagnosis of ICU acquired weakness in critically ill patients; a prospective observational study
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 94
- 试验地点
- 1
- 主要终点
- Specificity and sensitivity of the change in RF muscle thickness for diagnosis of ICU acquired weakness
研究概览
简要总结
In critically ill patients, ICU-acquired muscle weakness results from a combination of muscle and nerve pathology, and early identification of this entity is challenging. The diagnosis is commonly made based on clinical examination requiring the cooperation of the patient. In this study, we will enroll adult patients admitted to ICU on mechanical ventilation for at least 48 hours. The quadriceps muscle will be evaluated by an ultrasound machine and thickness, cross-sectional area, echogenicity, and pennation angle will be noted. The measurements will be taken at the time of ICU admission, 3rd day, and on the 5th day. On day 5, the ICU-acquired muscle weakness will be assessed using the Medical Research Council (MRC) sum scale. The diagnostic accuracy of ultrasound muscle parameters for ICU-acquired muscle weakness will be evaluated.
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 18.00 Year(s) 至 70.00 Year(s)（—）
- 性别
- All
入选标准
- •Anticipated ICU stay of at least 7 days -Sequential Organ Failure Assessment (SOFA) score≥ 8 at the time of enrollment.
排除标准
- •Patients with any known neuro-muscular diseases, such as myopathy, multiple sclerosis, or paraplegia
- •Amputated lower limbs
- •Patients with surgery on lower limbs
- •Patients who have been transferred from another hospital after a stay of 48 hours
- •Presence of tracheostomy on admission
- •History of ICU admission for at least 7 days in the last 3 months.
结局指标
主要结局
Specificity and sensitivity of the change in RF muscle thickness for diagnosis of ICU acquired weakness
时间窗: 0 day (ICU admission), 3rd day, 5th day
次要结局
- Specificity and sensitivity of change in RF cross sectional area, echogenicity and pennation angle for diagnosis of ICU acquired muscle weakness(0 day (ICU admission), 3rd day, 5th day)
研究者
Sukhyanti Kerai
Maulana Azad Medical College