Comparing organic bone replacement material from egg shell with man-made materials in rate of bone healing after lower wisdom tooth removal

Phase 3

Not yet recruiting

• Conditions: Patients undergoing surgical removal of Impacted lower third molar teeth under local anaesthesia; Impacted teeth,

• Registration Number: CTRI/2022/04/041859
• Lead Sponsor: Saveetha Dental College

Brief Summary

Use of various bone graft substitutes are advised to prevent bone loss, periodontal problems and enhance bone formation. Choice of the graft substitute depend on the biological properties and the cost of the material. Hence, a preliminary study was planned to evaluate the effectiveness of eggshell derived nano hydroxyapatite as an emerging graft substitute for the enhancement of bone regeneration.

Hydroxyapatite (HA) is apatite calcium phosphate. In many disciplines of surgery HA is being used as graft material successfullyIn particular, HA shows highest level of bioactivity and forms a quick bond with bone.A recent study showed bioactive effect of the HA ceramic is because of the ability to concentrate active fibronectin on its surface.Hydroxyapatite is available in porous/dense block or granular form for clinical use.  It is an inorganic ceramic substance which does not cause any foreign body reaction; in porous grafts the hard tissue grows into it and mingles with natural tissues.

The eggshell formulations have been used since the beginning as trace element and mineral supplying agents.The eggshell powder has been examined in rats for bone healing. Few studies show surface modified eggshell powder as osteoconductive bone filling material with variable benefit in bone regeneration.The literature showed material properties of egg- shell-derived hydroxyapatite (EHA) are superior when compared with the commercially available graft materials.So, the EHA has been introduced as bone graft substitute recently. Histomorphometric evaluation showed that the EHA has excellent new bone formation ability.This has led to the curiosity to prepare the EHA from eggshell waste in a very economical way.

Detailed Description

Not available

Study Timeline

• Study Start: 2022-04-15
• Last Update Posted: 2022-11-04

Recruitment & Eligibility

• Status: Not Yet Recruiting
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

• 1. Patients undergoing bilateral mandibular 3rd molar extraction 2. Patients with no associated pathologies and medical conditions or any medications that might alter the healing potential.
• ASA 1 and ASA 2.

Exclusion Criteria

• Medically compromised patients 2.
• Patients with unilateral impacted lower third molars 3.
• History of systemic diseases 5.
• Pregnant patients.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
1. Bone regeneration: Verified using CBCT	1. 1 month, 3 months, 6 months

Secondary Outcome Measures

Name	Time	Method
Wound healing - clinical examination	1 month

Trial Locations

Locations (1)

Saveetha Dental College and Hospitals; 🇮🇳 Chennai, TAMIL NADU, India

Saveetha Dental College and Hospitals

🇮🇳Chennai, TAMIL NADU, India

J JAYINDHRAESWARAN

Principal investigator

7200500633

Eshwaran.jjjj@gmail.com