TB Duration Study

Not Applicable

• Conditions: Health Condition 1: H359- Unspecified retinal disorder

• Registration Number: CTRI/2020/03/023957
• Lead Sponsor: Hyderabad Eye Resesarch Foundation

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 6 February 2023

Recruitment & Eligibility

• Status: Open to Recruitment
• Sex: Not specified
• Target Recruitment: 0

Inclusion Criteria

1.Symptoms ï?£3 months

Objective evidence of active intraocular inflammation compatible with TPU

e.g. active retinal vasculitis (with FA leakage) or choroidal lesions

2. Positive results of tuberculin skin test (TST, ï?³10 mm induration after 48 hours with 5TU) and/or interferon gamma release assay (Quantiferon TB Gold or T-SPOT)

3. May have evidence of healed pulmonary or other TB (but not requiring ATT for that disease)

4. Age >18 years, not pregnant or willing to use double contraception

Exclusion Criteria

Ophthalmic findings or ancillary test results consistent with non-TB diagnosis

Objective findings showing only non-active disease eg. occluded retinal vessels only, with no FA leakage from non-occluded vessels, or atrophic/scarred choroidal lesions

1.Optic nerve involvement

2.Past history of uveitis

3.Previous ATT for ocular or other disease

4.Concurrent active pulmonary or other TB disease requiring ATT for that disease.

5.HIV infection and other immunocompromised patients

6.Treated with systemic or local corticosteroids within 3 months prior to entry

7.Received anti-VEGF injections within 3 months prior to entry

8.Age less than 18 years

9.Pregnancy

10.Liver disease

11.Likelihood of poor compliance/ refusal to participate in study

Study & Design

• Study Type: Interventional
• Study Design: Not specified