Comparison of an automated weaning programme and a standard clinical weaning protocol for weaning critically ill patients

Not Applicable

Completed

• Conditions: Process of weaning from mechanical ventilation; Respiratory

• Registration Number: ISRCTN82559457
• Lead Sponsor: Guy's and St. Thomas' NHS Foundation Trust (UK)

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2005-09-30
• Last Update Posted: 17 October 2016

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 500

Inclusion Criteria

Added as of 10/12/2007:
Major entry criteria (suspected or proven infection, presence of a systemic response to the infection within the 48-hour period immediately preceding enrolment into the study, have or have had one or more sepsis-induced organ failures within the 48-hour period immediately preceding enrolment into the study).
1. Age >=18 years
2. Acute Physiology and Chronic Health Evaluation II (APACHE II) score =10
3. Precipitating injury (surgery, trauma, hypovolemia, episode of infection or sepsis) occurred within the last 48 hours before Intensive Care Unit (ICU) entry
4. Expected Length Of Stay (LOS) in the ICU >3 days
5. Indication for enteral nutrition for 5-10 days
6. Start of nutritional therapy with Intestamin or control supplement within 24 hours after inclusion criteria are fulfilled

Exclusion Criteria

1. Under 18 years of age
2. Requirement for high doses of vasopressor
3. Body temperature greater than 39ºC or less than 36ºC
4. GCS = 12 without or with minimal sedation
5. 'Do Not Resuscitate' order or expected short term prognosis
6. Patients chronically ventilated at home with tracheostomy
7. Patients with primary neurological cause of ventilator dependence
8. Pregnancy
9. Prolonged cardiac arrest with poor neurological prognoses
10. Inability to obtain consent from patient or legal representative

Study & Design

• Study Type: Interventional
• Study Design: Not specified