Development of A Technique to Predict Antidepressant Responsiveness in Depressive Patients

Samsung Medical Center1 site in 1 country300 target enrollmentOctober 1999

ConditionsDepression Continuous Antidepressant Abuse Adverse Reaction to Drug

InterventionsSSRI treated group

DrugsSSRI treated group

Overview

Phase: Not Applicable
Intervention: SSRI treated group
Conditions: Depression
Sponsor: Samsung Medical Center
Enrollment: 300
Locations: 1
Primary Endpoint: Antidepressant Response at 2,4,6 weeks
Last Updated: 10 years ago

Overview Investigators Eligibility Criteria Arms & Interventions Outcomes Sites Similar Trials

Overview

Brief Summary

First, the investigators examined the functional relevance of serotonin transporter polymorphisms by quantifying the activity of serotonin transporter in blood platelets of genotyped healthy volunteers and patients with major depression.

Second, the investigators studied response to SSRIs in relation to 5-HTTLPR genotype and also to the functional expression of 5-HTT in platelets.

Detailed Description

The purpose of this study is 1. to determine whether serotonin transporter genotypic or functional differences between depressive patients and normal controls were existed. 2. to determine the relationship between serotonin transporter polymorphisms and serotonin transporter functional expression. 3. to determine whether genomic or functional differences between drug responders and nonresponders predict the response of antidepressant

Registry

clinicaltrials.gov

Start Date

October 1999

End Date

December 2016

Last Updated

10 years ago

Study Type

Interventional

Study Design

Single Group

Sex

All

Investigators

Sponsor

Samsung Medical Center

Responsible Party

Principal Investigator

Doh Kwan Kim

M.D.,Ph.D.

Samsung Medical Center

Eligibility Criteria

Inclusion Criteria

•Eligible patients were enrolled in the clinical trials program of hte Samsung Medical Center Geropsychiatry and Affective Disorder Clinics(Seoul, Korea). They received a semistructured diagnostic interview, the Samsung Psychiatric Evaluation Schedule. The affective disorder section of the Samsung Psychiatric Evaluation Schedule uses the Korean version of the structured clinical interview for the diagnostic and statistical manual of mental disorders, Fourth edition.
•interview with one more patient's family member for objective diagnosis and final diagnosis decision by agreements of two more psychiatric physicians

Exclusion Criteria

•received psychotropic medication within 2 weeks of the study or fluoxetine within 4 weeks
•potential study participants for pregnancy, significant medical conditions, abnormal laboratory baseline values, unstable psychiatric features(eg.suicidal), history of alcohol of drug dependence, seizures, head trauma with loss of consciousness, neurological illness, or concomitant Axis I psychiatric disorder.