JPRN-UMIN000011085已完成未知
Influence of Multidrug resistance protein 4 (MRP4) on serum uric acid levels and uric acid clearance after multiple administration of trichlormethiazide in Japanese healthy volunteers: open-label study - Influence of MRP4 on serum uric acid levels and uric acid clearance after multiple administration of trichlormethiazide
Department of Clinical Pharmacology, Fuculty of Medicical Science, Kyushu University0 个研究点目标入组 60 人开始时间: 2013年7月1日最近更新:
适应症
试验速览
- 阶段
- 未知
- 状态
- 已完成
- 发起方
- 入组人数
- 60
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 年龄范围
- 20years-old 至 50years-old（—）
- 性别
- All
入选标准
- 未提供
排除标准
- •1.Disease that should be treated 2. On medical treatment 3. Hepatic dysfunction(AST>40 IU/L or ALT>40 IU/L) 4. Renal dysfunction (serum creatinine level>1.2 mg/dL) 5. History of cardiovascular disease 6. Serum uric acid level >7.5 mg/dL 7. Abnormal electrolytes values (Na or K) 8. Hematocrit >55 % 9. Allergy reaction to thiazide and its related diuretics 10. Woman who is pregnant or breastfeeding 11. Systolic blood pressure <90 mmHg or >140 mmHg (sitting position) 12. Body weight <40 kg or >90 kg 13. Not appropriate to this study by other reasons
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