Influence of Multidrug resistance protein 4 (MRP4) on serum uric acid levels and uric acid clearance after multiple administration of trichlormethiazide in Japanese healthy volunteers: open-label study
Not Applicable
- Conditions
- hyperuricemia
- Registration Number
- JPRN-UMIN000011085
- Lead Sponsor
- Department of Clinical Pharmacology, Fuculty of Medicical Science, Kyushu University
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete: follow-up complete
- Sex
- All
- Target Recruitment
- 60
Inclusion Criteria
Not provided
Exclusion Criteria
1.Disease that should be treated 2. On medical treatment 3. Hepatic dysfunction(AST>40 IU/L or ALT>40 IU/L) 4. Renal dysfunction (serum creatinine level>1.2 mg/dL) 5. History of cardiovascular disease 6. Serum uric acid level >7.5 mg/dL 7. Abnormal electrolytes values (Na or K) 8. Hematocrit >55 % 9. Allergy reaction to thiazide and its related diuretics 10. Woman who is pregnant or breastfeeding 11. Systolic blood pressure <90 mmHg or >140 mmHg (sitting position) 12. Body weight <40 kg or >90 kg 13. Not appropriate to this study by other reasons
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Relation between MRP4 genotype and the changes of serum uric acid levels and uric acid clearance after multiple administration of trichlormethiazide
- Secondary Outcome Measures
Name Time Method Change of serum electrolytes, cholesterol, triglycerides, pulse rate and blood pressure Ratio of side effects by trichlormethiazide