Efficacy of Ultrasound-guided Transverse Abdominal Plane Block for Analgesia in Renal Transplantation
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Renal Insufficiency, Chronic
- Sponsor
- Federal University of São Paulo
- Enrollment
- 42
- Locations
- 1
- Primary Endpoint
- Morphine Consumption
- Last Updated
- 8 years ago
Overview
Brief Summary
The objective of this study is to evaluate the efficacy and safety of transverse abdominal plane block in patients undergoing renal transplant surgery.Adult renal transplant recipients will be prospectively randomized to receive a standard general anesthetic technique supplemented with ropivacaine 0.375% 20 mL TAP block or sham block with 20 mL 0.9% saline. Both groups will receive patient-controlled morphine analgesia. Patient assessment will occur in the postanesthetic care unit and at 1, 2, 4, 6, 12, and 24 hours. The primary outcome is total morphine consumption in the first 24 hours after renal transplantation. Other outcomes asses include pain scores, presence of nausea or vomiting, excessive sedation, and respiratory depression.
Investigators
Leonardo Henrique Cunha Ferraro
Professor
Federal University of São Paulo
Eligibility Criteria
Inclusion Criteria
- •end-stage renal disease undergoing cadaveric renal transplantation
Exclusion Criteria
- •Contraindications to the use of morphine
- •Contraindications to the use ropivacaine
- •Peripheral neuropathy
- •Inability to use a Patient Control Analgesia device
Outcomes
Primary Outcomes
Morphine Consumption
Time Frame: 24 hours post-operative
Patient Control Analgesia: morphine sulfate 2 mg IV every 5 minutes until visual analog scale pain score (0 = no pain, 10 = worst possible pain) is 3 or less, and continued at the following settings for a 24-hour period: 1 mg bolus, 7-minute lockout, and 30 mg maximum 4-hourly dose.
Secondary Outcomes
- Pain Score(24 hours post-operative)