Investigating potential treatments for human lung injury in healthy volunteers
- Conditions
- Acute Respiratory Distress Syndrome (ARDS)Respiratory
- Registration Number
- ISRCTN16086655
- Lead Sponsor
- Belfast Health and Social Care Trust
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Ongoing
- Sex
- All
- Target Recruitment
- 30
Healthy non-smoking adults aged 18-45 years old
1. Age <18 years
2. Age >45 years
3. BMI >30 kg/m2
4. On concomitant medications including over-the-counter medications excluding hormonal contraception and paracetamol
5. Previous adverse reactions to LPS, lignocaine or sedative agents
6. Pregnant or breast-feeding
7. Participation in a clinical trial of an investigational medicinal product within 30 days
8. Consent declined
9. History of asthma or other respiratory conditions
10. Smoking or e-cigarette use
11. Marijuana use or other inhaled products (with or without nicotine) in the last 3 months
12. Alcohol abuse, as defined by the Alcohol Use Disorders Identification Test (AUDIT)
13. Subjects with history of prior conventional cigarette (> 100 cigarettes lifetime and smoking within 6 months) or electronic cigarette use.
14. Live vaccine with in preceeding 4 weeks
15. Abnormal blood count, renal function or liver function tests identified at screening
16. History of shingles
17. History of Hepatitis B/C
18. Allergy to Baricitinib
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Broncho-alveolar lavage neutrophil count during bronchoscopy at day 4
- Secondary Outcome Measures
Name Time Method Broncho-alveolar lavage fluid/Plasma/Urine: cytokines including but not limited to Il-6, IL-10, IL-18, CXCL8, IL-1b, markers of epithelial and endothelial injury including but not limited to RAGE, SP-D, Ang2, single-cell RNA sequencing, plasma differential white cell count, BAL differential white cell count, plasma C-reactive protein