ISRCTN16086655进行中（未招募）1 期
Inhaled lipopolysaccharide challenge as a human model to investigate potential therapies in Acute Respiratory Distress Syndrome
适应症
试验速览
- 阶段
- 1 期
- 状态
- 进行中（未招募）
- 入组人数
- 30
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 性别
- All
入选标准
- •Healthy non-smoking adults aged 18-45 years old
排除标准
- •1. Age <18 years
- •2. Age >45 years
- •3. BMI >30 kg/m2
- •4. On concomitant medications including over-the-counter medications excluding hormonal contraception and paracetamol
- •5. Previous adverse reactions to LPS, lignocaine or sedative agents
- •6. Pregnant or breast-feeding
- •7. Participation in a clinical trial of an investigational medicinal product within 30 days
- •8. Consent declined
- •9. History of asthma or other respiratory conditions
- •10. Smoking or e-cigarette use
- •11. Marijuana use or other inhaled products (with or without nicotine) in the last 3 months
- •12. Alcohol abuse, as defined by the Alcohol Use Disorders Identification Test (AUDIT)
- •13. Subjects with history of prior conventional cigarette (> 100 cigarettes lifetime and smoking within 6 months) or electronic cigarette use.
- •14. Live vaccine with in preceeding 4 weeks
- •15. Abnormal blood count, renal function or liver function tests identified at screening
- •16. History of shingles
- •17. History of Hepatitis B/C
- •18. Allergy to Baricitinib
研究者
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