Impaired IGF-1 Generation Causes Protein Catabolism and Poor Growth in Children With Crohn Disease
试验速览
- 阶段
- 不适用
- 状态
- 终止
- 入组人数
- 1
- 试验地点
- 1
- 主要终点
- Height velocity
研究概览
简要总结
The investigators will prospectively recruit 26 children with moderate - severe active Crohn disease (PCDAI >30). Results will be compared to 26 patients in sustained remission (PCDAI <10 and physician global assessment of remission over the previous 6 months) who are matched for age and gender. Subjects will be studied at baseline and six months. The primary study end-points will be leucine rate of appearance (a measure of protein breakdown) and IGF-1 levels.
This study will test the hypothesis that children with greater disease severity will have worse longitudinal growth and protein catabolism. The investigators will also explore the secondary hypothesis that children with Crohn disease have abnormal IGF-1 generation which is linked to underlying inflammation and disease severity.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Prospective
入排标准
- 年龄范围
- 5 Years 至 15 Years（Child）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Diagnosed with Crohn disease by endoscopy and histologic samples
- •Chronological and/or bone age 6-15 years old
- •Tanner 1 - 2
- •Willing to participate in our longitudinal evaluation
排除标准
- •Concomitant persistent chronic infectious disease
- •Inflammatory bowel disease not diagnosed as Crohn disease
- •Immunological disorder (excluding Crohn disease)
- •Associated severe concomitant chronic illnesses (CF, liver failure)
- •Pregnancy
结局指标
主要结局
Height velocity
时间窗: 6 months
次要结局
- Protein catabolism(6 months)