Role of Inflammation in Progressive Multifocal Leukoencephalopathy (PML)
- Conditions
- Progressive Multifocal Leukoencephalopathy
- Registration Number
- NCT01132053
- Lead Sponsor
- Beth Israel Deaconess Medical Center
- Brief Summary
This is a continuation of our previous studies on Progressive Multifocal Leukoencephalopathy (PML). We will focus on the role of inflammation in PML, and define prognostic markers of disease evolution.
- Detailed Description
To determine precisely what are the host or viral factors that may predict a favorable outcome for PML patients and the role of inflammation in preventing JCV from causing brain disease. One of the goals of this study is to help establish non-invasive markers of PML evolution by studying the brain metabolism in PML lesions using Magnetic Resonance Imaging (MRI), Magnetic Spectroscopy (MRS) and other advanced imaging modalities.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 126
- PML patients of 18 years of age or older will be included in this study.
- Presence of opportunistic brain lesions other than PML. ( e.g., toxoplasmosis, lymphoma)
- Presence of confounding neurological disorder such as brain neoplasm etc.
In addition patients with a contraindication to MRI examination will be excluded from study. Contraindications to the MRI examination include:
- Medically unstable or hematological, renal, or hepatic dysfunction.
- Cardiac pacemaker
- Internal clips,
- Metal implants, or external clips with 10 mm of the head.
- Metal in the eyes.
- Pregnant
- Claustrophobia
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Beth Israel Deaconess Medical Center
🇺🇸Boston, Massachusetts, United States