Evaluation effect intrauterine administration of peripheral blood lymphocyte cells on expression of endometrial estrogen and progesterone receptor

Phase 3

• Conditions: Infertility.; Female infertility, unspecified; N97.9

• Registration Number: IRCT20140707018381N3
• Lead Sponsor: Shahid Beheshti University of Medical Sciences

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 3 April 2023

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 22

Inclusion Criteria

At least =3 previous implantation failure in IVF or ICSI cycles
No history of clinical pregnancy (primary infertility)
not receiving any steroidal hormone = 2 months were entered in this study

Exclusion Criteria

genetic disorders
history of repeated infectious diseases
Endometriosis
uterine anatomic abnormalities

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
The mRNA levels of both estrogen receptors and progesterone receptors in endometrial tissues. Timepoint: at the implantation window time, during the mid-secretory phase (LH+7 days) of each menstrual cycle. Method of measurement: The sample of tissue is analyzed using the quantitative real-time polymerase chain reaction (qRT-PCR) technique.

Secondary Outcome Measures

Name	Time	Method
The protein expression estrogen receptors and progesterone receptors in endometrial tissues. Timepoint: at the implantation window time, during the mid-secretory phase (LH+7 days) of each menstrual cycle. Method of measurement: immunohistochemical staining.