NCT01336335Unknown3 期
The Effects of Continuous Positive Airway Pressure (CPAP) on Sympathetic Activity in Different Sites of Activation
适应症
试验速览
- 阶段
- 3 期
- 入组人数
- 20
- 试验地点
- 1
- 主要终点
- improvement in sympathetic activity in muscle sympathetic nerve activity (MSNA)
研究概览
简要总结
Recent evidences suggest that obstructive sleep apnea (OSA) can contribute to cardiovascular disease even in the absence of hypertension. However, there are few data regarding the impact of OSA on the sympathetic system in apparently normotensive patients with OSA as well as the impact of treatment with continuous positive airway pressure in different sites of activation (heart, peripheral nerves and circulating catecholamines)
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 30 Years 至 60 Years（Adult）
- 性别
- Male
- 接受健康志愿者
- 否
入选标准
- •Severe OSA males
排除标准
- •Sustained Hypertension
- •Heart failure
- •Renal diseases
- •Under use of any medication
- •Under treatment for OSA
结局指标
主要结局
improvement in sympathetic activity in muscle sympathetic nerve activity (MSNA)
时间窗: 3 months
Improvement in MSNA will be quantified as burst frequency over time (bursts per minute) and as burst frequency corrected for heart rate values (bursts per 100 heartbeats)in the begining and after 3 months.
次要结局
- improvement in sympathetic activity evaluated in different sites of activation(3 months)
研究者
研究点 (1)
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