The Effects of Inspiratory Muscle Training on Endurance Performance in Trained Athletes Under Normoxic and Hypoxic Conditions: A Gender-based Comprehensive Study

Not Applicable

Not yet recruiting

• Conditions: Hypoxia, Altitude
• Interventions: Procedure: Normal Breathing; Procedure: Inspiratory Muscle Training (IMT)

• Registration Number: NCT06121128
• Lead Sponsor: University of Lausanne

Brief Summary

The POWERbreathe™ Plus: an Inspiratory Muscle Training device (IMT) with adjustable resistance.

Intervention lasts 4 weeks, with a frequency of 6 days/week, 2 series of 30 inspirations in the morning and evening.

Resistance based on 60% of the Pressure Maximal Inspiratory (PMI). Progressive increase in resistance every week.

Four laboratory visits: 2 pre-tests and 2 post-tests. Each pre- / post- test will go under normoxic and hypoxic conditions.

Measurements include Pulmonary functions (spirometry test); blood microcirculation (vascular occlusion test); gas exchanges (e.g. VO2max), cardiac parameters, heart rate variability, maximal aerobic power (incremental and time limit test)

Detailed Description

The POWERbreathe™ Plus: an Inspiratory Muscle Training device (IMT) with adjustable resistance.

Intervention lasts 4 weeks, with a frequency of 6 days/week, 2 series of 30 inspirations in the morning and evening.

Resistance based on 60% of the Pressure Maximal Inspiratory (PMI). Progressive increase in resistance every week.

Four laboratory visits: 2 pre-tests and 2 post-tests. Each pre- / post- test will go under normoxic and hypoxic conditions.

Measurements include Pulmonary functions (spirometry test); blood microcirculation (vascular occlusion test); gas exchanges (e.g. VO2max), cardiac parameters, heart rate variability, maximal aerobic power (incremental and time limit test)

Study Timeline

• Study First Submitted: 2023-10-30
• Status Verified: 2023-11
• Study First Submitted QC: 2023-11-05
• Last Update Submitted: 2023-11-05
• Study First Posted: 2023-11-07
• Last Update Posted: 2023-11-07
• Study Start: 2023-12-01
• Primary Completion: 2024-06-30
• Study Completion: 2024-08-31

Recruitment & Eligibility

• Status: NOT_YET_RECRUITING
• Sex: All
• Target Recruitment: 48

Inclusion Criteria

• Inclusion: endurance trained athletes between 18 and 44 years old

Exclusion Criteria

cardiovascular, metabolic and respiratory diseases, smoking history, prescription medication (Two medication families are known to interfere with FC:

• Calcium channel blockers
• Beta-blockers

Two families are known to interfere during spirometry measurements:

• Inhaled beta-agonists
• Inhaled glucocorticoids)

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Male Control Group (MCON)	Normal Breathing	male endurance trained athletes between 18 and 44 years old
Female Control Group (FCON)	Normal Breathing	female endurance trained athletes between 18 and 44 years old
Female Training Group (FTRAIN)	Inspiratory Muscle Training (IMT)	female endurance trained athletes between 18 and 44 years old
Male Training Group (MTRAIN)	Inspiratory Muscle Training (IMT)	male endurance trained athletes between 18 and 44 years old

Primary Outcome Measures

Name	Time	Method
sex-differences	One week prior and in the week immediately following the intervention	Primary objective: To assess the change of a time limit duration in ergocycle after 4 weeks of inspiratory muscle training (IMT) between males and females.
Effect in hypoxia	One week prior and in the week immediately following the intervention	Secondary objective: To assess the change of a time limit duration in ergocycle after 4 weeks of inspiratory muscle training (IMT) between hypoxia and normoxia.