Gated 13N-NH3 PET before and during hemodialysis for the assessment of changes in myocardial perfusion, volumes and output of the left ventricle.

Recruiting

Conditions: 10082206
cardiac perfusion
left ventricular function

Registration Number: NL-OMON30270

Lead Sponsor: niversitair Medisch Centrum Groningen

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: Not specified

Target Recruitment: 8

Inclusion Criteria

1) Adult (age equal to/above 18) HD patients who have been treated with HD for at least six months. 2) Patients must have an arterio-venous fistula without recirculation established by Transonic flow measurements.

Exclusion Criteria

1. The absence of informed consent (see ethical considerations). 2. The need to perform HD with pre-dilution. 3. Recent haemorrhage. 4. Unstable angina pectoris. 5. History of myocardial infarction. 6. Inability to endure a horizontal position for a longer period of time. 7. Arrhythmia. 8. The use of long-acting nitrates. 9. Left ventricular ejection fraction <= 30%. 10. Diabetes Mellitus. 11. Pregnancy or suspicion hereof.

Study & Design

Study Type: Observational invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The outcome parameters are changes in cardiac output, myocardial contractility,<br /><br>left ventricular ejection fraction, left ventricular diameter, left ventricular<br /><br>end-systolic volume, left ventricular end-diastolic volume, left ventricular<br /><br>myocardial perfusion in ml/min/g and regional wall motions. Data will be<br /><br>analysed quantitatively and displayed in a 17-segment polar map. Each<br /><br>individual session will be evaluated for pre- and post-study body weight, total<br /><br>ultrafiltration volume, blood pressure and the course of relative blood volume<br /><br>(measured non-invasively by an RBV monitor) throughout the study. </p><br>

Secondary Outcome Measures