ISRCTN34410935
Completed
未知
A pilot study to examine the safety and efficacy of intravitreal ranubizumab/dexamethasone administration and oral minocycline in addition to Visudyne (verteporfin) photodynamic therapy for subfoveal choroidal neovascularization secondary to age-related macular degeneration: an open-label trial
King's College Hospital NHS Foundation Trust (UK)0 sites20 target enrollmentMay 30, 2008
Overview
- Phase
- 未知
- Intervention
- Not specified
- Conditions
- Not specified
- Sponsor
- King's College Hospital NHS Foundation Trust (UK)
- Enrollment
- 20
- Status
- Completed
- Last Updated
- 8 years ago
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •1\. The patient must be willing to give written informed consent
- •2\. The patient must be able to undertake the necessary tests and treatment and be willing to be followed up
- •3\. Age 50 years or older
- •4\. Clinical diagnosis of AMD
- •5\. Subfoveal CNV confirmed by fluorescein angiography
- •6\. Logarithmic minimal angle of resolution (LogMAR) best corrected visual acuity of 24 \- 73 letters on early treatment diabetic retinopathy study (ETDRS) chart
Exclusion Criteria
- •1\. Inability to understand or sign consent form
- •2\. The patient has a current medical condition or history of a medical condition that would be likely to preclude scheduled study visits such as unstable angina, dialysis, and active cancer
- •3\. Patient has a current ophthalmic condition or history of an ophthalmic condition that might compromise the assessment of the treatment such as diabetic retinopathy, uveitis, amblyopia, ischaemic optic neuropathy
- •4\. Signs of a myopic retina or refraction of greater than \-8 dioptres in their current or any previous glasses prescription
- •5\. Signs of other retinal conditions that may have caused the CNV such as angioid streaks, choroidal rupture, and old chorio\-retinitis
- •6\. Open angle glaucoma
- •7\. At increased risk of developing glaucoma such as having pigment dispersion syndrome or pseudoexfoliation
- •8\. Unable to have a good quality fluorescein angiogram taken, e.g., due to head tremor or media opacity
- •9\. Known hypersensitivity to fluorescein or any of the study medications
- •10\. Previous treatment for a retinal detachment
Outcomes
Primary Outcomes
Not specified
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