Analysis of the Variation in Caspase-8 Availability and Cleavage in Oral Squamous Cell Carcinoma
试验速览
- 阶段
- 不适用
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- Caspase-8 activity in oral cancer and its impact on disease progression
研究概览
简要总结
Control of cell death is frequently disrupted in cancer resulting in overgrowth of tumour cells. Caspase-8 is a key enzyme involved in controlling cell death. This study examines the importance of caspase-8 in oral cancer.
详细描述
Control of cell death is frequently disrupted in cancer resulting in overgrowth of tumour cells. The caspase family of enzymes are the key performers of controlled cell death and caspase-8 is frequently mutated in oral cancer. This study will perform DNA sequencing to determine if the gene is wild-type (not mutated). The abundance of inactive (uncleaved) and active (cleaved) caspase-8 will be determined. The levels of the proteins that caspase-8 interacts with (including caspase-3) will be determined. Results will be correlated with tumour stage, patient outcome and the presence of immune cells and other microscopic features. This will improve the understanding of the importance of caspase-8 in oral cancer.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Oral cancer
- •Sufficient follow up data
排除标准
- •Patient has indicated that they do not wish their tissue to be used for research.
- •. The quantity or quality of tissue is too little or poor to provide adequate material without significant reserve.
- •The material contains bone.
结局指标
主要结局
Caspase-8 activity in oral cancer and its impact on disease progression
时间窗: Up to 3 years
Molecular analysis of caspase-8 activity will be undertaken and correlated with tumour features and outcome.
次要结局
未报告次要终点