D-tecting Disease - From Exposure to Vitamin D During Critical Periods of Life
- Conditions
- ArthritisObesityDiabetes MellitusPre-EclampsiaCongenital DisordersAsthmaBirth WeightBirth DisorderCancerVitamin D Deficiency
- Interventions
- Other: D-tect
- Registration Number
- NCT03330301
- Lead Sponsor
- Bispebjerg Hospital
- Brief Summary
Vitamin D deficiency is common among otherwise healthy pregnant women and may have consequences for them as well as the early development and long-term health of their children. However, the importance of maternal vitamin D status has not been widely studied.
The present study is divided into a societal experiment (1) and a case-cohort study (2):
1. The present study includes an in-depth examination of the influence of exposure to vitamin D early in life and during critical periods of growth for development of type 1 diabetes (T1D), type 2 diabetes, gestational diabetes, pre-eclampsia, obesity, asthma, arthritis, cancer, mental and cognitive disorders, congenital disorders, dental caries and bone fractures during child- and adulthood. The study is based on the fact that mandatory fortification of margarine with vitamin D, which initiated in 1937, was terminated in 1985.
Apart from determining the influences of exposure prior to conception and during pre- and postnatal life, the investigators examined the importance of vitamin D exposure during specific seasons and trimesters, by comparing disease incidence among individuals born before and after the fortification.
2. Additionally, a validated method was used to determine neonatal vitamin D status using stored dried blood spots (DBS) from individuals who develop the aforementioned disease entities as adults and their time and gender-matched controls.
Unparalleled, the study will help determine the effects of vitamin D exposure during critical periods in life. There are a sufficient number of individuals to verify any effects during different gestation phases and seasons of the year. The results, which will change our current understanding of the significance of vitamin D, will enable new research in related fields, including interventional research designed to assess supplementation needs for different subgroups of pregnant women. Also, other health outcomes can subsequently be studied to generate multiple new interdisciplinary health research opportunities involving vitamin D.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 222776
- Born in Denmark around the fortification period
- Sufficient amount of blood from the DBS
1.Born outside Denmark
- Born outside the fortification period
- Insufficient amount of blood from the DBS or DBS not found
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description Exposed D-tect 1. Individuals born between June1983 and May1985 were exposed to the mandatory vitamin D margarine fortification during fetal life. 2. Cases: individuals defined as having one of the aforementioned diseases of interest from the registers Non-exposed D-tect 1. Individuals born between September1986 and August 1988 were not exposed to the mandatory vitamin D margarine fortification during fetal life. 2. Controls: cohort of matched disease-free individuals
- Primary Outcome Measures
Name Time Method Pre-eclampsia 2012-2025 Register based
Bone facture 2012-2025 Register based
Obesity 2012-2025 Register based
Type 1 diabetes 2012-2016 Register based
- Secondary Outcome Measures
Name Time Method Type 2 diabetes 2014-2025 Register based
Arthritis 2018-2025 Register based
Mental diseases 2012-2025 Register based
Asthma 2015-2025 Register based
Birth weight 2014-2019 Register based
Gestational diabetes 2014-2025 Register based
Trial Locations
- Locations (1)
Parker Institute
🇩🇰Frederiksberg, Denmark