Effect of Intravenous Ceftriaxone and Oral Doxycycline for Lyme Neuroborreliosis
- Registration Number
- NCT00138801
- Lead Sponsor
- Sorlandet Hospital HF
- Brief Summary
The aim of this study is to compare parenteral ceftriaxone and oral doxycycline in the treatment of neuroborreliosis in a randomized controlled trial.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 120
Inclusion Criteria
-
Neurological symptoms and/or findings consistent with neuroborreliosis and at least one of the following fulfilled:
- Intrathecal production of borrelia antibodies;
- White cell count in cerebrospinal fluid (CSF) > 5/mm3;
- Significant rise in borrelia antibodies in two serum samples collected from a patient with at least 3 weeks interval;
- Verified acrodermatitis chronica atrophicans.
Exclusion Criteria
- Allergy to the contents in the medication, or earlier type I reaction to penicillin.
- Treatment with cephalosporins, penicillin or tetracyclins during the last 14 days
- Pregnancy or breastfeeding
- Age < 18 years
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description 1 Doxycycline Doxycycline 2 Ceftriaxone cephtriaxone
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method
Related Research Topics
Explore scientific publications, clinical data analysis, treatment approaches, and expert-compiled information related to the mechanisms and outcomes of this trial. Click any topic for comprehensive research insights.
What molecular mechanisms underlie ceftriaxone's efficacy in treating neuroborreliosis compared to doxycycline?
How does the comparative effectiveness of intravenous ceftriaxone versus oral doxycycline impact long-term outcomes in Lyme Neuroborreliosis patients?
Are there specific biomarkers that can predict response to ceftriaxone or doxycycline in neuroborreliosis treatment?
What are the known adverse events associated with ceftriaxone and doxycycline for neuroborreliosis and how are they managed?
How do combination therapies involving ceftriaxone and doxycycline compare to monotherapies in treating Lyme Neuroborreliosis?
Trial Locations
- Locations (1)
Sørlandet Sykehus HF
🇳🇴Kristiansand, Vest-Agder, Norway
Sørlandet Sykehus HF🇳🇴Kristiansand, Vest-Agder, Norway