Effects of noninvasive ventilation after cardiovascular surgery: A Randomized Clinical Trial
Not Applicable
- Conditions
- Respiration, artificialthoracic surgeryanoxia
- Registration Number
- RBR-8jgwpr
- Lead Sponsor
- Alessandra Preisig
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- data analysis completed
- Sex
- Not specified
- Target Recruitment
- Not specified
Inclusion Criteria
Postoperative cardiovascular surgery (valve replacement, thoracoabdominal aortic surgery and/or coronary artery bypass graft (CABG);
Sternal incision and pulmonary artery catheter from surgical ward
Both genders, aged between 18 and 80 years.
Exclusion Criteria
Severe chronic obstructive pulmonary disease,
Previous neurological disease and inability to understand;
More than 24 hours on mechanical ventilation;
Surgical revision for bleeding after tracheal extubation;
Emergency surgery;
Swan-Ganz catheter nonfunctioning
Study & Design
- Study Type
- Intervention
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The study hypothesis was that could improve gas exchange (oxygenation index, partial pressure of oxygen in arterial blood and arterial oxygen saturation) with the use of bilevel noninvasive ventilation. To evaluate this outcome, we collected blood samples (arterial blood gases) at four time points: baseline, one hour and three hours after the placement of the mask and one hour after stopping the intervention.<br>
- Secondary Outcome Measures
Name Time Method The analysis of hemodynamic variables was made by measuring the pulmonary artery catheter (Swan-Ganz) that was inserted into the surgical ward, via the internal jugular vein. The following variables were measured: heart rate (HR), mean arterial pressure (MAP), mean pulmonary artery pressure (MPAP), central venous pressure (CVP) and pulmonary capillary wedge pressure (PCWP). To measure the cardiac output (CO), 10ml of saline (0.9%) were injected manually at room temperature and was calculated by the thermodilution curve. All measurements were repeated 4-5 times, excluding outliers and held an average of three measurements. Indirect variables obtained: cardiac index (CI), systolic volume index (SVI), left ventricular stroke work index (LVSWI), right ventricle stroke work index (RVSWI), systemic vascular resistance index (SVRI) and pulmonary vascular resistance index (PVRI). <br>