a Cohort Study of Ischemic Cerebrovascular Disease

Recruiting

• Conditions: Ischaemic Stroke
• Interventions: Other: Intravenous thrombolysis

• Registration Number: NCT05922540
• Lead Sponsor: Xiangya Hospital of Central South University

Brief Summary

This study aims to establish a multicenter, large-scale, prospective cohort of patients with ischemic stroke. Various biological samples such as blood, feces, and urine are collected to identify biomarkers associated with ischemic stroke. By integrating demographic information, clinical indicators, imaging parameters, and biomarker parameters, the study aims to develop risk assessment, early warning, and prognosis prediction models. Additionally, the study aims to identify key genes and explore relevant signaling pathways related to ischemic stroke.

Detailed Description

Not available

Study Timeline

• Study Start: 2022-11-01
• Status Verified: 2023-06
• Study First Submitted: 2023-06-19
• Study First Submitted QC: 2023-06-27
• Last Update Submitted: 2023-06-27
• Study First Posted: 2023-06-28
• Last Update Posted: 2023-06-28
• Primary Completion: 2026-11-01
• Study Completion: 2027-11-01

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 5000

Inclusion Criteria

1. Clinical diagnosis of ischemic stroke.
2. Age ≥ 18 years.
3. Signed informed consent form.

Exclusion Criteria

1. Patients with moderate to severe mental disorders or dementia who cannot cooperate to complete the informed consent and follow-up procedures.
2. Patients with neurological functional impairment caused by conditions such as migraine aura, epilepsy, or other non-ischemic strokes.
3. Agitated patients who cannot cooperate with imaging examinations.
4. Pregnant or lactating patients, as well as those planning to become pregnant within 90 days.
5. Patients with concurrent malignant tumors or severe systemic diseases with an expected survival period of less than 90 days.
6. Patients who have participated in other clinical studies within 30 days prior to enrollment or are currently participating in other interventional clinical studies.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
those with favorable prognosis	Intravenous thrombolysis	-
those with unfavorable prognosis	Intravenous thrombolysis	-

Primary Outcome Measures

Name	Time	Method
Cerebrovascular events	3 months of onset in patients	Cerebrovascular events, including ischemic stroke, transient ischemic attack, cerebral hemorrhage, subarachnoid hemorrhage
mRS scores	3 months of onset in patients	Assessing patients' neurological functional impairment status using the mRS score

Trial Locations

Locations (1)

Xiangya Hospital, Central South University; 🇨🇳 Hunan, China