Safety study of hydrogen gas inhalation for pulmonary oxygenation disorders in patients with acute aortic dissection Stanford type B

Kawata Mitsuhiro0 个研究点目标入组 10 人开始时间: 2021年2月2日最近更新: 2023年10月17日

适应症

试验速览

暂无简介。

•1. 40 years or older at the time of consent
•2. Patients diagnosed with Stanford type B due to acute aortic dissection
•3. Patients who can perform hydrogen gas inhalation therapy within 24 hours after entering the intensive care unit
•4. Patients who understand the content of this study and can obtain written consent from the patient

•1. Patients with traumatic aortic dissection
•2. Patients with rupture due to acute aortic dissection or scheduled for emergency surgery including stent graft
•3. Patients suspected of having a bacterial infection, such as elevated procalcitonin levels before the start of hydrogen gas inhalation therapy
•4.Patients clinically suspected of having a fungal infection before the onset of acute aortic dissection. (Whether or not there is a suspicion of a fungal infection will be determined by the attending physician based on clinical symptoms before the start of hydrogen inhalation. In addition, based on the results of beta-D-glucan before the start, cases with strong suspicion of fungal infection should be discontinued immediately after diagnosis.)
•5. Patients with severe liver dysfunction equivalent to Grade C in the Child-Pugh classification
•6. Patients with renal dysfunction requiring dialysis
•7. Patients taking immunosuppressive drugs
•8. Patients who have started or will start ventilator or ECMO
•9. Patients with or suspected of having lung disorders (pneumonitis, COPD)
•10.Patients with poor respiratory function who require 50 percent or more FiO2 to maintain PaO2. (Reservoir mask 15 L per min with FiO2 50 percent, PaO2 less than 60 mmHg)
•11. Patients with or suspected of having cancer
•12. Other patients who the investigator has determined to be ineligible for this study

发起方

Kawata Mitsuhiro