ACTRN12620000557932
Completed
未知
Therapies to prevent progression of COVID-19, including Hydroxychloroquine, Azithromycin, Zinc, Vitamin D with or without Vitamin C, a multi-centre, international, randomized trial: The International ALLIANCE Study - Stage 1
AProf Dr Karin Ried0 sites446 target enrollmentMay 11, 2020
Overview
- Phase
- 未知
- Intervention
- Not specified
- Conditions
- COVID-19
- Sponsor
- AProf Dr Karin Ried
- Enrollment
- 446
- Status
- Completed
- Last Updated
- 3 years ago
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Diagnosis of active COVID\-19
- •Provision of informed consent in writing, can be electronic
Exclusion Criteria
- •1\) Known G6PD deficiency
- •2\) Contra\-indication to hydroxychloroquine, azithromycin or Vitamin C: allergy to study interventions, epilepsy, serious hearing or visual problems, history of severe depression, calcium oxalate stones, advanced liver disease, pregnancy or lactating
- •3\) Already receiving chloroquine, azithromycin, more than 3 grams Vitamin C daily or an experimental antiviral
- •4\) History of fever (e.g. night sweats, chills) and/or acute respiratory infection (e.g. cough, shortness of breath, sore throat) of more than 7 days’ duration. Note, if study numbers not quickly reached, the investigators may decide to include those with symptoms of longer than 7 days
- •5\) Calculated creatinine clearance of less than 30 mL/minute
- •6\) Baseline ECG showing: QTc greater than or equal to (\>\=) 470 for males, QTc greater than or equal to (\>\=) 480 for females
- •7\) Receipt of a drug known to increase QTc: quetiapine, amiodarone, sotalol
Outcomes
Primary Outcomes
Not specified
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