Investigating the Feasibility of Using Rapid Cine-MRI for Monitoring Moving and Deforming Tumors
Overview
- Phase
- Not Applicable
- Status
- Terminated
- Enrollment
- 17
- Locations
- 1
- Primary Endpoint
- To measure time series of MRI imaging by the b-SSFP sequence.
Overview
Brief Summary
In this study, the researchers investigate the feasibility of using rapid cine MR imaging to provide both offline and online soft-tissue-based image guidance. Such images will provide a significantly more complete picture of the spatial and temporal changes in thoracic anatomy. This more complete information will lay the groundwork for better radiotherapy planning and dose delivery in the presence of respiratory motion.
Detailed Description
Rapid MRI scans from Stage I-IV non-small-cell lung cancer (NSCLC) patients will be acquired. MR acquisition will be performed without extrinsically administered contrast, using a balanced turbo field echo (TFE) sequence and commercially available coils.
Study Design
- Study Type
- Interventional
- Allocation
- Na
- Intervention Model
- Single Group
- Primary Purpose
- Other
- Masking
- None
Eligibility Criteria
- Ages
- 18 Years to 99 Years (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •AJCC Stage I, II, III or IV non-small-cell lung cancer to be treated using radiotherapy will be eligible for this study.
- •Any types and amounts of prior therapy will be allowed for this study.
- •Subjects must be greater than or equal to 18 years of age. There are no gender or ethnic restrictions.
- •Ability to understand and the willingness to sign a written informed consent document.
- •Able to tolerate supine position
- •ECOG performance status of 3 or less
Exclusion Criteria
- •MRI-incompatible metallic implants, embedded metallic objects, implanted biomedical devices e.g., cardiac pacemakers
- •Women who are pregnant or trying to get pregnant
- •Pain in supine position
Outcomes
Primary Outcomes
To measure time series of MRI imaging by the b-SSFP sequence.
Time Frame: 6 weeks
To use fast acquisition sequences to obtain 2D and 3D cine MR images of moving and deforming lung tumors. The signal to noise ration (SNR) and spatiotemporal resolution of imaging sequences will be optimized into a format potentially useful for radiotherapy guidance.
Secondary Outcomes
No secondary outcomes reported