Evaluation Of The Adjunctive Use Of Albuminated Platelet Rich Fibrin (Alb-PRF) Versus Injectable Platelet Rich Fibrin (i-PRF) In Non-Surgical Periodontal Therapy: A Split-Mouth Randomized Clinical Trial
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 21
- 试验地点
- 1
研究概览
简要总结
Platelet-Rich Fibrin (PRF) is a second-generation autologous platelet concentrate commonly used in regenerative dentistry because it improves wound healing and tissue repair. It is made without anticoagulants or added chemicals, making it a simple, cost-effective, and biologically safe option. PRF includes a fibrin matrix rich in platelets and leukocytes, which gradually release growth factors. This supports soft tissue healing, new blood vessel formation, and periodontal regeneration. In periodontology, PRF has become important as a supplement to both surgical and non-surgical treatments because it promotes tissue repair and reduces inflammation. With improvements in centrifugation methods, new PRF formulations have been created to enhance handling and biological effectiveness. Injectable Platelet-Rich Fibrin (i-PRF) is a liquid version obtained through low-speed centrifugation. Its injectable form allows for easy delivery into periodontal pockets after scaling and root planing. It solidifies after application, forming a fibrin network at the site and improving healing and tissue response in non-surgical periodontal therapy. Albuminated Platelet-Rich Fibrin (Alb-PRF) is a modified version of PRF that adds thermally treated albumin to the fibrin matrix. This change aims to improve structural stability and extend its absorption time. It is believed to offer a longer-lasting regenerative effect and better support properties compared to standard liquid PRF. While both i-PRF and Alb-PRF show potential for regeneration, there is limited clinical evidence comparing their effectiveness as supplements in non-surgical periodontal therapy. Therefore, this split-mouth randomized clinical trial seeks to evaluate and compare the use of Alb-PRF and i-PRF in patients undergoing non-surgical periodontal treatment. The findings of this study will help assess the relative clinical effectiveness of Alb-PRF and i-PRF as supplements to non-surgical periodontal therapy. This will also support evidence-based decision-making in periodontal practice
研究设计
- 研究类型
- Interventional
- 分配方式
- Coin toss, Lottery, toss of dice, shuffling cards etc
- 盲法
- Participant and Outcome Assessor Blinded
入排标准
- 年龄范围
- 25.00 Year(s) 至 65.00 Year(s)（—）
- 性别
- All
入选标准
- •1.Systemically healthy adults aged 25 to 65 years, of either gender 2.Periodontitis individuals with presence of bilateral periodontal pockets involving at least 2 interproximal sites in the posterior teeth maxilla or mandible suitable for split mouth allocation.
- •3.Presence of a minimum of 20 natural teeth overall, with at least 4 teeth in the quadrant of interest.
- •4.Patients who are willing to participate, provide written informed consent and comply with study procedures and scheduled follow up visits.
排除标准
- •1.History of periodontal therapy within the previous 6 months.
- •2.History of use of antibiotics, anti inflammatory drugs, corticosteroids, or immunosuppressive therapy within the last 3 months.
- •3.Sites with grade four furcation involvement , or grade two and three mobility.
- •4.Teeth with endodontic lesions or restorations or serving as abutments for FPD.
- •5.Individuals with known systemic diseases or conditions that may affect periodontal status or wound healing .
- •7.Smokers or users of any form of tobacco.
- •8.Pregnant or lactating women.
- •9.Individuals with poor oral hygiene compliance.
研究者
Samyukdha S K
SRM Dental college