Diastolic Function in Myotonic Dystrophy Type 1

Recruiting

• Conditions: Diastolic Dysfunction

• Registration Number: NCT06029192
• Lead Sponsor: Centre d'Investigation Clinique et Technologique 805

Brief Summary

Myotonic dystrophy type 1 (DM1) is a neuromuscular disorder in relation with an unstable expansion of CTG repeat. Patients with DM1 are at risk of arrhythmia and conduction disorders. Mortality are mainly related to respiratory failure and sudden death. Patients with DM1 may suffer from obesity, arterial hypertension, diabetes mellitus and sleep apnea. These comorbidities are classically associated with left ventricular diastolic dysfunction (DD) .

The investigators aim to assess the prevalence of left ventricular diastolic dysfunction in patients with myotonic dystrophy type 1 , the distribution of DD grading as well as the long-term prognosis of DM1 patients with a left ventricular diastolic dysfunction.

Detailed Description

Not available

Study Timeline

• Study Start: 2023-06-02
• Study First Submitted: 2023-07-21
• Status Verified: 2023-09
• Study First Submitted QC: 2023-09-07
• Last Update Submitted: 2023-09-07
• Study First Posted: 2023-09-08
• Last Update Posted: 2023-09-08
• Primary Completion: 2023-10-02
• Study Completion: 2023-11-01

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 500

Inclusion Criteria

• patients with genetic proven myotonic dystrophy type 1
• who experienced a Doppler- Echocardiography including an assessment of the left ventricular diastolic function

Exclusion Criteria

• wall motion basal abnormalities
• significant valvular disease

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
mortality	7 years

Secondary Outcome Measures

Name	Time	Method
Incidence of arrhythmia	7 years
acute heart failure	7 years

Trial Locations

Locations (1)

Hopital Raymond Poincare; 🇫🇷 Garches, France