Impact of Catheter Ablation of Ventricular Arrhythmias on Suboptimal Biventricular Pacing in Cardiac Resynchronization Therapy

Completed

• Conditions: Ventricular Premature Complexes; Systolic Heart Failure; Ventricular Tachycardia; Reduced Biventricular Pacing; Cardiac Resynchronization Therapy
• Interventions: Procedure: Catheter ablation of ventricular arrhythmia; Drug: Intensified medical therapy

• Registration Number: NCT04065893
• Lead Sponsor: Universitätsklinikum Köln

Brief Summary

Cardiac resynchronization therapy reduces mortality in patients with systolic heart failure and left bundle branch block. Reduced biventricular pacing can lead to therapy failure. Most effective mortality reduction was seen with a BiV pacing above 98%.

Reduced BiV pacing is a common phenomenon with potential impact on CRT-response and pts' prognosis. Frequent ventricular ectopy may be associated with attenuated benefit from CRT. The investigators sought to systematically assess the effect of ventricular arrhythmia treatment on BiV pacing.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2019-08-16
• Study First Submitted QC: 2019-08-21
• Study First Posted: 2019-08-22
• Study Start: 2020-09-01
• Primary Completion: 2021-08-01
• Study Completion: 2021-08-01
• Status Verified: 2021-11
• Last Update Submitted: 2021-11-05
• Last Update Posted: 2021-11-15

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 65

Inclusion Criteria

• reduced biventricular pacing <98% due to ventricular arrhythmia

Exclusion Criteria

• reduced biventricular pacing <98% due to other cause
• age <18
• pregnancy

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Catheter ablation group	Catheter ablation of ventricular arrhythmia	Patients with reduced biventricular pacing due to PVC or VT receiving catheter ablation of PVC/VT according to guidelines and clinical practices
Medical treatment group	Intensified medical therapy	Patients with reduced biventricular pacing due to PVC or VT receiving intensified medical therapy (antiarrhythmics/betablocker) according to guidelines and clinical practices

Primary Outcome Measures

Name	Time	Method
Percentage of Biventricular pacing	3 month after intervention biventricular pacing (%) is routinely monitored	Influence of intervention (Ablation/medical treatment) on previously reduced biventricular pacing percentage (\<98%). Biventricular pacing is measured in percentage of stimulation and is monitored at routine device interrogation.

Trial Locations

Locations (1)

University Hospital Cologne; 🇩🇪 Cologne, NRW, Germany