NCT03046849已完成不适用
Diagnosis of Lynch Syndrome Based on Next-generation Sequencing in Colorectal Cancer Patients Meeting Chinese Lynch Syndrome Criteria: An Open-label and Multi-center Study.
Second Affiliated Hospital, School of Medicine, Zhejiang University3 个研究点 分布在 1 个国家目标入组 100 人开始时间: 2017年3月8日最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 100
- 试验地点
- 3
- 主要终点
- Pathogenic germline mutation
研究概览
简要总结
The purpose of this study is to find out the proportion of patients diagnosed with Lynch syndrome in colorectal cacner patients meeting Chinese Lynch syndrome criteria. Besides, this study is aimed to analyze the clinical characteristics and germline mutation of Lynch syndrome in Chinese population.
详细描述
- Detect germline mutation (by next-generation squencing) in probands.
- Verify the germline mutation in blood relatives whose proband has known germline mutation(s).
- Analyze the test data with clinical and family information. Diagnose Lynch syndrome in the included population.
- Analyze the clinical characteristics and germline mutation of Lynch syndrome in Chinese population.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Retrospective
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- 未提供
排除标准
- 未提供
结局指标
主要结局
Pathogenic germline mutation
时间窗: Upon completion of study, on average 2 years.
Pathogenic germline mutation using next-generation sequencing with a targeted panel.
次要结局
- Variant of uncertain significance of germline mutation(Upon completion of study, on average 2 years.)
研究者
Ying Yuan, MD
Professor, Department of Medical Oncology
Second Affiliated Hospital, School of Medicine, Zhejiang University
研究点 (3)
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