The comparison of salivary levels of specialised pro-resolving mediators,resolvins and lipoxin among smokers and non-smokers before and after non-surgical periodontal therapy
- Conditions
- HEALTHY HUMAN VOLUNTEERS WITH PERIODONTITIS
- Registration Number
- CTRI/2022/04/042292
- Lead Sponsor
- ARTHI I
- Brief Summary
Periodontitis is an immunoinflammatorydisease of the supporting structures of the dentition which is initiated by perio-pathogens that triggers the cellsof the immune system to release proinflammatory mediators resulting ininflammation and destruction of the periodontium. The primary goal of the periodontaltherapy is to ensure resolution of inflammation and restoration of the tissuehomeostasis. Cigarette smoking is known to be a majorrisk factor for periodontal disease and also affects the healing response of patientsafter periodontal therapy. A ‘programmed resolution’ at the tissuelevel has been actively driven by several specialized lipid immune resolventsincluding resolvins and lipoxins. The role of resolvins and lipoxins in response to non-surgicalperiodontal therapy has not been elucidated in smokers with periodontitis.Further, salivary levels of resolvins (RvE1) and lipoxins (LXA4) andtheir association with periodontal therapy among smokers and non-smokers hasnot been studied. Therefore, in this study, we aim toevaluate and compare the salivary levels of resolvins (RvE1) and lipoxins (LXA4) inperiodontitis patients before and after non-surgical treatment between smokersand non-smokers. Most metabolites, cytokines, products ofinflammation including RvE1 and LXA4 ongoing in periodontium move in a certainamount by passive filtration into saliva and their levels in saliva reflecttheir levels in plasma.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Male
- Target Recruitment
- 40
1.Patients with more than 20 teeth 2.Current cigarette smokers ≤ 10 cigarettes per day 3.Periodontitis patients with probing pocket depth(PPD) ≥ 5mm and interdental clinical attachment level(CAL) ≥4mm 4.Patients who are complying with oral hygiene instructions and periodontal recall 5.Patients who are willing to participate in the study.
- 1.Pregnant and lactating women 2.Patients using medication affecting the periodontal status.
- 3.Patients with history of periodontal therapy for the past six months 4.Patients with inflammatory disorders such as rheumatoid arthritis, diabetes mellitus, COPD, inflammatory bowel disease etc.
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method SALIVARY LEVELS OF RESOLVIN AND LIPOXIN BEFORE AND AFTER NON-SURGICAL PERIODONTAL THERAPY AT BASELINE AND 4 WEEKS AFTER NON SURGICAL PERIODONTAL THERAPY
- Secondary Outcome Measures
Name Time Method To compare the salivary levels of resolvins and lipoxins before and after non-surgical periodontal therapy between smokers and non-smokers and to correlate it with clinical parameters.
Trial Locations
- Locations (1)
SRM DENTAL COLLEGE AND HOSPITAL
🇮🇳Chennai, TAMIL NADU, India
SRM DENTAL COLLEGE AND HOSPITAL🇮🇳Chennai, TAMIL NADU, IndiaARTHI IPrincipal investigator8610368835ashwiniarthi26@gmail.com