Lung and Diaphragm Ultrasound Evaluation During Weaning From Mechanical Ventilation in COVID-19 Patients

Completed

• Conditions: Diaphragm Ultrasound; COVID-19; Lung Ultrasound; Weaning
• Interventions: Other: Point-of-Care Ultrasound

• Registration Number: NCT05706441
• Lead Sponsor: Second Affiliated Hospital, School of Medicine, Zhejiang University

Brief Summary

The goal of this observational study is to learn about the function of lung and diaphragm ultrasound during weaning from mechanical ventilation in COVID-19 patients. The aim of this study was that the lung ultrasound score and diaphragm muscle mobility could be a potential predictive factor of weaning success.

Detailed Description

Not available

Study Timeline

• Status Verified: 2023-01
• Study Start: 2023-01-11
• Study First Submitted: 2023-01-18
• Study First Submitted QC: 2023-01-29
• Study First Posted: 2023-01-31
• Primary Completion: 2023-03-30
• Study Completion: 2023-03-30
• Last Update Submitted: 2023-04-24
• Last Update Posted: 2023-04-27

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 35

Inclusion Criteria

• age > 18 years,
• critically ill patients with COVID-19 (defined as those requiring mechanical ventilation due to respiratory failure), and eligible for their first SBT according to the attending physician's judgement that the underlying disease which led to intubation had sufficiently resolved.

Exclusion Criteria

• patients with previous cardiothoracic surgery or pleurodesis and patients who presented with stridor (due to upper airway involvement) as a cause of extubation failure
• neuromuscular disease

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
ultrasound	Point-of-Care Ultrasound	Pulmonary and diaphragm ultrasound was evaluated within one hour before withdrawal

Primary Outcome Measures

Name	Time	Method
The primary end-point was to verify the lung and diaphragm ultrasound evaluation if the predicts weaning success/failure from mechanical ventilation	spontaneous-breathing trial started until 48 hours following extubation	Weaning failure was defined as failure to pass the spontaneous-breathing trial or the need for re-intubation within 48 h following extubation

Secondary Outcome Measures

Name	Time	Method
The secondary outcome was to verify the predictive value of the traditional weaning parameters	spontaneous-breathing trial started until 48 hours following extubation	Weaning failure was defined as failure to pass the spontaneous-breathing trial or the need for re-intubation within 48 h following extubation

Trial Locations

Locations (1)

The Second Affiliated Hospital of Zhejiang University anesthesiology department; 🇨🇳 Hangzhou, Zhejiang, China