An Open Labelled Active-controlled Randomized Clinical Study To Evaluate The Efficacy Of Ashwagandhadi Churna In Tamak Shwasa With Special Reference to Bronchial Asthma

Bronchial Asthma is a chronic inflammatory disorder of the airways involving various cells and cellular components. This inflammation causes airway hyper-responsiveness, leading to repeated episodes of wheezing, breathlessness, chest tightness, and coughing, especially during the night or early morning. Over the past few decades, the prevalence of asthma has increased, affecting individuals of all age groups. It is now recognized as a major contributor to global disability. While genetics play a role in the development and progression of asthma, the rapid rise in its prevalence points to the significant influence of environmental factors. A key feature of asthma is airway hyper-reactivity, where the airways respond excessively to harmless triggers. The loss of immune tolerance to inhaled allergens is considered a leading cause of asthma, resulting in an abnormal immune response. In Ayurveda, Bronchial Asthma is correlated with Tamaka Shwasa, a chronic disorder of the pranavaha srotas that disturbs daily activities with symptoms like cough and difficulty in breathing. Tamaka Shwasa is identified as a Swatantra Vyadhi with distinct causes and treatments. Classical texts describe it as a palliative or difficult-to-cure disease, requiring proper management and lifestyle adaptations. Pathologically, Tamaka Shwasa occurs due to an imbalance of Kapha and Vata doshas, often triggered by cold, dry food or seasonal changes, leading to airway obstruction. Ayurvedic formulations like Ashwagandhadi churna help in managing the condition by pacifying Vata and removing Kapha-induced blockages in the airways. Globally, asthma affects around 300 million people, with numbers expected to rise to 400 million by 2025. It is more prevalent in males, with a 2 to 1 male to female ratio. Asthma remains a major health concern, particularly in low and middle income countries, contributing to high treatment costs and productivity losses.