Clinical Usefulness of Cortisol, Antinuclear Antibodies and High-sensitivity C-reactive Protein in Acute Pancreatitis

• Conditions: Acute Pancreatitis
• Interventions: Diagnostic Test: Measurement of cortisol

• Registration Number: NCT03830060
• Lead Sponsor: Assiut University

Brief Summary

Acute pancreatitis (AP) is a potentially life-threatening disease with varying severity of presentation. Nearly 60%-80% of all cases of AP in developed countries are attributable to either gallstone disease or alcohol abuse. The incidence is similar in both sexes, although alcohol abuse is the more common cause in men and gallstones is the more common cause in women.

Detailed Description

Severe acute pancreatitis is one of the most common acute abdomens in clinical practice. Owing to its acute onset, rapid progress, and high mortality, it has become a hot clinical study spot and one of the toughest medical problems. Markers of inflammation, such as high-sensitivity CRP (hs-CRP), are predictive of the severity of acute pancreatitis and may be useful in identifying patients with severe acute pancreatitis in the early phase after onset.

Antinuclear antibodies (ANA) are important biomarkers for the autoimmune disorder. ANA may contribute to the pathogenesis of pancreatitis and ANA positivity is associated with the presence of autoimmune pancreatitis. Cortisol is released into the blood due to stimulation of corticotrophin receptors in the adrenal cortex. Thus, serum cortisol can be measured. Although the association between serum levels of some inflammatory marker and acute pancreatitis revealed, the relationship between ANA, cortisol, hs-CRP and with the severity of acute pancreatic lesions have not evaluated yet.

Study Timeline

• Status Verified: 2019-02
• Study First Submitted: 2019-02-02
• Study First Submitted QC: 2019-02-02
• Last Update Submitted: 2019-02-02
• Study First Posted: 2019-02-05
• Last Update Posted: 2019-02-05
• Study Start: 2019-02-25
• Primary Completion: 2019-05-20
• Study Completion: 2019-05-30

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 50

Inclusion Criteria

• abdominal pain consistent with AP
• serum amylase activity at least 3 times greater than the upper limit of normal
• Patients of age 18 years or more who are willing to participate in the study and give their consent for same.

Exclusion Criteria

• Patients with severe liver disease, pulmonary embolus, sepsis, and renal failure were excluded from the study.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Group II:	Measurement of cortisol	The previous AP patients after 72 hours
Group I:	Measurement of cortisol	Fifty AP patients on admission

Primary Outcome Measures

Name	Time	Method
The mean difference of cortisol before and after treatment	72 hours	Cortisol mean difference will be measured by immunofluorescence in acute pancreatitis.