The early use of steroid therapy in reducing chemotherapy induced myocarditis following cytoreductive surgery and hyperthermic intra-peritoneal chemotherapy in the early post-operative period: A retrospective study

Phase 1

• Conditions: Cancer

• Registration Number: PACTR202001797822250
• Lead Sponsor: ational cancer institute

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2019-12-31
• Last Update Posted: 29 May 2023

Recruitment & Eligibility

• Status: Pending
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

•Greater than or equal to 18 years of age.
•Clinical performance status of ECOG = 2.
•Stable serum CEA levels not indicating recurrence.
•No history of prior/other malignancies within the 2 years prior to enrollment with the exception of basal cell carcinoma.

Exclusion Criteria

•Active systemic infections, coagulation disorders, or other major medical illnesses precluding major surgery.
•Prior experimental therapy with novel agents.
•Prior HIPEC.
•History of brain metastases.
•Childs B or C cirrhosis or with evidence of severe portal hypertension by history, endoscopy, or radiologic studies or with evidence of moderate to severe ascites.
•Weight less than 40 kg.
•History of congestive heart failure and/or an LVEF < 40%.
•Significant COPD or other chronic pulmonary restrictive disease with PFT's indicating an FEV1 less than 50% or a DLCO less than 40% predicted for age.

Study & Design

• Study Type: Interventional
• Study Design: Not specified