The Effects of Cardiac Innervation on Intra-coronary t-PA Release
试验速览
- 阶段
- 不适用
- 状态
- 撤回
- 试验地点
- 1
- 主要终点
- T-PA release in the coronary artery bed.
研究概览
简要总结
Heart transplant recipients do not have nerves to their hearts. This protocol tests the hypothesis that bradykinin mediated t-PA release in the coronary arteries will be reduced in heart transplant recipients compared to healthy subjects.
This study will compare heart transplant recipients to healthy controls who are undergoing cardiac cath for standard of care purposes (separate protocol) and compare the coronary arteries to the forearm in transplant recipients (separate protocol) and healthy controls (separate protocol).
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- 未提供
排除标准
- 未提供
研究组 & 干预措施
Bradykinin
Patients have holter monitoring. Patients receive intracoronary bradykinin (0.2, 0.6, 2.0 ug/min) and have coronary sinus and coronary artery blood sampling for t-PA and O2 content.
干预措施: Bradykinin (Drug)
结局指标
主要结局
T-PA release in the coronary artery bed.
时间窗: Single Study Visit
次要结局
- Heart rate variability(Single study visit)
- Histopathology for arteriolar t-PA and sympathetic neurons(Single Study Visit)
研究者
James Muldowney
Assistant Professor
Vanderbilt University Medical Center