Blood thinners for high blood pressure in lungs - A Pilot Randomized Control Trial
- Conditions
- Health Condition 1: I270- Primary pulmonary hypertension
- Registration Number
- CTRI/2023/10/059337
- Lead Sponsor
- Indian Council of Medical Research
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Open to Recruitment
- Sex
- Not specified
- Target Recruitment
- 0
1.Age is =18 years
2. Patient consents to participation
3.Group 1 Pulmonary hypertension
4. WHO functional class II or III
5. All PAH patients documented by a diagnostic right heart catheterization (RHC) .
6. Patient must be on a stable doses of
pulmonary vasodilator therapy
1.Patient with a strong indication for anticoagulation i.e., Atrial fibrillation,CTEPH, thromboembolism, stroke
2.Acutely decompensated heart failure within 30 days3 months prior to randomisation
3.Left ventricular ejection fraction (LVEF) < 45% on echocardiogram (ECHO) or pulmonary capillary wedge pressure (PCWP) > 15 mmHg on right heart catheterization during baseline evaluation
4.PAH secondary to valvular heart disease
5.Stopped receiving any pulmonary hypertension chronic general supportive therapy (e.g, diuretics, oxygen, anticoagulants, digoxin) within 60 days prior to randomisation
6. WHO class IV
7. Contraindication to anticoagulation
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method