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临床试验/NCT01944501
NCT01944501已完成不适用

Neuromodulation Techniques in the Treatment of Chronic Tinnitus With Hearing Loss

University of Brasilia2 个研究点 分布在 1 个国家目标入组 36 人开始时间: 2012年3月1日最近更新:
适应症

试验速览

阶段
不适用
状态
已完成
发起方
入组人数
36
试验地点
2
主要终点
Change in Tinnitus Handicap Inventory (THI) scores

研究概览

简要总结

This study aimed at trying transcranial magnetic stimulation and transcranial direct current stimulation as potential treatments to decrease tinnitus in patients with significant hearing loss.

详细描述

Tinnitus is a very common condition and affects approximately 15% of the population, disrupting sleep, emotional balance and social life of the patients. Acoustic deprivation causes hearing loss and is responsible for a cascade of processes that result in the reorganization of the cortex through a synchronization of neuronal activity related to a cortical re-mapping. Consistent with the hypothesis that tinnitus is caused by abnormal activation of the auditory cortex, repetitive transcranial magnetic stimulation (rTMS) can temporarily reduce cortical hyperactivity through direct neuromodulation of the temporal cortex. Furthermore, studies have shown that transcranial direct current stimulation (tDCS) can also suppress tinnitus. Objective: To determine the effectiveness of rTMS and TDCS in the treatment of patients with chronic tinnitus and auditory loss. Methods: We performed an analytical experimental double-blind study using rTMS and tDCS in patients with chronic tinnitus and hearing loss.

研究设计

研究类型
Interventional
分配方式
Randomized
干预模型
Parallel
主要目的
Treatment
盲法
Double (Participant, Investigator)

入排标准

年龄范围
45 Years 至 70 Years(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • chronic tinnitus
  • hearing loss

排除标准

  • neurological diseases
  • use of drugs affecting the central nervous system
  • evidence of dementia
  • clinical diagnosis of depression

结局指标

主要结局

Change in Tinnitus Handicap Inventory (THI) scores

时间窗: THI was measured before intervention (baseline) and after 5 daily sessions (day 5)

次要结局

  • Change in Visual Analog Scale scores(Visual analog scale of tinnitus was recorded at baseline and after daily 5 TMS or TDCS sessions ( day 5))

研究者

发起方
University of Brasilia
申办方类型
Other
责任方
Principal Investigator
主要研究者

Joaquim Brasil-Neto

Dr.

University of Brasilia

研究点 (2)

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