Neuromodulation Techniques in the Treatment of Chronic Tinnitus With Hearing Loss
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 36
- 试验地点
- 2
- 主要终点
- Change in Tinnitus Handicap Inventory (THI) scores
研究概览
简要总结
This study aimed at trying transcranial magnetic stimulation and transcranial direct current stimulation as potential treatments to decrease tinnitus in patients with significant hearing loss.
详细描述
Tinnitus is a very common condition and affects approximately 15% of the population, disrupting sleep, emotional balance and social life of the patients. Acoustic deprivation causes hearing loss and is responsible for a cascade of processes that result in the reorganization of the cortex through a synchronization of neuronal activity related to a cortical re-mapping. Consistent with the hypothesis that tinnitus is caused by abnormal activation of the auditory cortex, repetitive transcranial magnetic stimulation (rTMS) can temporarily reduce cortical hyperactivity through direct neuromodulation of the temporal cortex. Furthermore, studies have shown that transcranial direct current stimulation (tDCS) can also suppress tinnitus. Objective: To determine the effectiveness of rTMS and TDCS in the treatment of patients with chronic tinnitus and auditory loss. Methods: We performed an analytical experimental double-blind study using rTMS and tDCS in patients with chronic tinnitus and hearing loss.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 45 Years 至 70 Years(Adult, Older Adult)
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •chronic tinnitus
- •hearing loss
排除标准
- •neurological diseases
- •use of drugs affecting the central nervous system
- •evidence of dementia
- •clinical diagnosis of depression
结局指标
主要结局
Change in Tinnitus Handicap Inventory (THI) scores
时间窗: THI was measured before intervention (baseline) and after 5 daily sessions (day 5)
次要结局
- Change in Visual Analog Scale scores(Visual analog scale of tinnitus was recorded at baseline and after daily 5 TMS or TDCS sessions ( day 5))
研究者
Joaquim Brasil-Neto
Dr.
University of Brasilia
