Comparative Study on Effect of Pharmacological Stress with Nicorandil and Adenosine to Diagnostic Performance of Myocardial Perfusion SPECT in Ischemic Heart Diseases

Kangwon National University Hospital0 个研究点目标入组 50 人开始时间: 待定最近更新: 2019年3月11日

试验速览

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•? suspected ischemic heart disease patient who will undergo coronary angiography
•a) previously healthy patient: no previous medical history with diagnosis of or treatment for coronary heart disease
•b) known ischemic heart disease patient: patient with new symptoms including chest pain, dyspnea, etc. within recent 1 month
•? both male and female patients aged over 40

•? Severe renal failure, hepatic failure, brain function disorders, hypotension, cardiogenic shoke, or other physical or psycological problems that make the patient difficult to participate in the current study
•? contraindications to adenosine or nicorandil as below:
•a) adenosine: hypersensitivity reaction, 2nd/3rd degree AV block, sick sinus syndrome, chronic obstructive pulmonary disease, long QT syndrome, severe hypotension, uncompensated heart failure, refractory unstable angina, dipyridamol use
•b) nicorandil: severe hepatic/renal dysfunction, severe brain dysfunction, severe hypotension or cardiogenic shock, Eisenmenger syndrome or primary hypertension, right ventricular infarction, dehydration symptoms, neurocirculatory asthenia,
•narrow angle glaucoma, history of hypersensitiveness to nicorandil or nitric acid/nitrite ester agents, use of phosphodiesterase-5 (PDE-5) or guanylate cyclase
•? pregnancy or breast feeding

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