Furosemide Stress Test Predicting Early Graft Function in Kidney Transplantation

Not Applicable

Recruiting

• Conditions: Delayed Graft Function; Kidney Function; Kidney Transplant; Complications
• Interventions: Drug: Furosemide Injection

• Registration Number: NCT03071536
• Lead Sponsor: King Chulalongkorn Memorial Hospital

Brief Summary

Furosemide is an old drug that has been used frequently in the postoperative period of kidney transplantation, aiming to achieve adequate urine output. There is no previous study that directly evaluate the urine response to standardized dose of furosemide in the postoperative period. The objective is to measure the urine output after standardized dose of furosemide is delivered, as a biomarker to predict the graft function in perioperative period.

Detailed Description

Not available

Study Timeline

• Study Start: 2016-11-25
• Study First Submitted: 2017-02-20
• Study First Submitted QC: 2017-03-01
• Study First Posted: 2017-03-07
• Status Verified: 2024-01
• Last Update Submitted: 2024-01-15
• Last Update Posted: 2024-01-17
• Primary Completion: 2026-05
• Study Completion: 2027-05

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 180

Inclusion Criteria

• Deceased donor kidney transplantation at KCMH
• informed consent is accepted

Exclusion Criteria

• Known allergy to furosemide
• Surgical complication of allograft
• Urgently needed for dialysis (refractory hypervolemia, uremic symptoms, and hyperkalemia)

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Furosemide	Furosemide Injection	Single dose of furosemide 1.5 mg/kg intravenously will be given to all participants at 3 hours post-reperfusion of kidney allograft. Urine output will be recorded hourly for 6 hours.

Primary Outcome Measures

Name	Time	Method
Urine output	6 hours	Urine output per hour (milliliters/hour) after furosemide injection

Secondary Outcome Measures

Name	Time	Method
Delayed graft function	7 days	Delayed graft function is defined by the necessity of dialysis within the first week after kidney transplantation. (yes/no)
Creatinine reduction ratio	At postoperative day 0,7 and 14	Ratio of serum creatinine at postoperative day 7 and 14 to day-zero creatinine

Trial Locations

Locations (1)

King Chulalongkorn Memorial Hospital; 🇹🇭 Bangkok, Thailand