A Study of ASP2215 Versus Salvage Chemotherapy in Patients With Relapsed or Refractory Acute Myeloid Leukemia (AML) With FMS-like Tyrosine Kinase (FLT3) Mutation

Phase 3

Completed

Conditions: Leukemia, Acute Myeloid (AML)

Interventions: Drug: gilteritinib
Drug: LoDAC (Low Dose Cytarabine)
Drug: Azacitidine
Drug: MEC (Mitoxantrone, Etoposide, Cytarabine)
Drug: FLAG-IDA (Granulocyte-Colony Stimulating Factor (G-CSF), Fludarabine, Cytarabine, Idarubicin)

Registration Number: NCT02421939

Lead Sponsor: Astellas Pharma Global Development, Inc.

Brief Summary: The purpose of this study is to determine the clinical benefit of ASP2215 therapy in participants with FMS-like tyrosine kinase (FLT3) mutated acute myeloid leukemia (AML) who are refractory to or have relapsed after first-line AML therapy as shown with overall survival (OS) compared to salvage chemotherapy, and to determine the efficacy of ASP2215 therapy as assessed by the rate of complete remission and complete remission with partial hematological recovery (CR/CRh) in these participants.

This study will also determine the overall efficacy in event-free survival (EFS) and complete remission (CR) rate of ASP2215 compared to salvage chemotherapy.

Detailed Description: Participants considered an adult according to local regulations at the time of signing informed consent may participate in this study. Participants will be randomized in a 2:1 ratio to receive ASP2215 or salvage chemotherapy. Participants will enter the screening period up to 14 days prior to the start of treatment. Prior to randomization, a salvage chemotherapy regimen will be pre-selected for each participant; options will include low-dose cytarabine (LoDAC), azacitidine, mitoxantrone, etoposide, and intermediate-dose cytarabine (MEC), or fludarabine, cytarabine, and granulocyte colony-stimulating factor (G-CSF) with idarubicin (FLAG-IDA). The randomization will be stratified by response to first-line therapy and pre-selected salvage chemotherapy. Participants will be administered treatment over continuous 28-day cycles.

After treatment discontinuation, participants will have a pre-hematopoietic stem cell transplant (HSCT)/end-of-treatment visit within 7 days after treatment discontinuation, followed by a 30-day follow-up for safety, in which a telephone contact with the participant is sufficient unless any assessment must be repeated for resolution of treatment-related adverse events (AEs). After that, long term follow-up will be done every 3 months up to 3 years from the participant's end-of-treatment visit.

Recruitment & Eligibility

Status: COMPLETED

Sex: All

Target Recruitment: 371

Inclusion Criteria

Participant has a diagnosis of primary acute myeloid leukemia (AML) or AML secondary to myelodysplastic syndrome (MDS) according to WHO classification (2008) as determined by pathology review at the treating institute.
Participant is refractory to or relapsed after first-line AML therapy (with or without hematopoietic stem cell transplant (HSCT)).
- Refractory to first-line AML therapy is defined as:
  1. Participant did not achieve complete remission/complete remission with incomplete hematologic recovery/complete remission with incomplete platelet recovery (CR/CRi/CRp) under initial therapy. A Participant eligible for standard therapy must receive at least one cycle of an anthracycline containing induction block in standard dose for the selected induction regimen. A Participant not eligible for standard therapy must have received at least one complete block of induction therapy seen as the optimum choice of therapy to induce remission for this subject.
- Untreated first hematologic relapse is defined as:
  1. Participant must have achieved a CR/CRi/CRp (criteria as defined by [Cheson et al, 2003], see Section 5.3) with first line treatment and has hematologic relapse.
Participant is positive for FLT3 mutation in bone marrow or whole blood as determined by the central lab. A Participant with rapidly proliferative disease and unable to wait for the central lab results can be enrolled based on a local test performed after completion of the last interventional treatment. Participants can be enrolled from a local test result if they have any of the following FLT3 mutations: FLT3 internal tandem duplication (ITD), FLT3 tyrosine kinase domain (TKD)/D835 or FLT3- TKD/I836.
Participant has an Eastern Cooperative Oncology Group (ECOG) performance status ≤ 2.
Participant is eligible for pre-selected salvage chemotherapy.
Participant must meet the following criteria as indicated on the clinical laboratory tests:
- Serum aspartate aminotransferase and alanine aminotransferase ≤ 2.5 x upper limit of normal (ULN)
- Serum total bilirubin ≤ 1.5 x ULN
- Serum creatinine ≤ 1.5 x ULN or an estimated glomerular filtration rate of > 50 mL/min as calculated by the Modification of Diet in Renal Disease equation.
Participant is suitable for oral administration of study drug.
Female Participant must either:
- Be of non-child bearing potential:
  1. post-menopausal (defined as at least 1 year without any menses) prior to Screening, or
  2. documented as surgically sterile (at least 1 month prior to Screening)
- Or, if of childbearing potential,
  1. Agree not to try to become pregnant during the study and for 180 days after the final study administration
  2. And have a negative urine pregnancy test at Screening
  3. And, if heterosexually active, agree to consistently use highly effective contraception per locally accepted standards in addition to a barrier method starting at Screening and throughout the study period and for 180 days after the final study drug administration.
Female Participant must agree not to breastfeed at Screening and throughout the study period and for 60 days after the final study drug administration.
Female Participant must not donate ova starting at Screening and throughout the study period and for 180 days after the final study drug administration.
Male Participant and their female partners who are of childbearing potential must be using highly effective contraception per locally accepted standards in addition to a barrier method starting at Screening and continue throughout the study period and for 120 days after the final study drug administration.
Male Participant must not donate sperm starting at Screening and throughout the study period and 120 days after the final study drug administration.
Participant agrees not to participate in another interventional study while on treatment.

Exclusion Criteria

Participant was diagnosed as acute promyelocytic leukemia (APL).
Participant has BCR-ABL-positive leukemia (chronic myelogenous leukemia in blast crisis).
Participant has AML secondary to prior chemotherapy for other neoplasms (except for MDS).
Participant is in second or later hematologic relapse or has received salvage therapy for refractory disease
Participant has clinically active central nervous system leukemia.
Participant has been diagnosed with another malignancy, unless disease-free for at least 5 years. Participants with treated nonmelanoma skin cancer, in situ carcinoma or cervical intraepithelial neoplasia, regardless of the disease-free duration, are eligible for this study if definitive treatment for the condition has been completed. Participants with organ-confined prostate cancer with no evidence of recurrent or progressive disease are eligible if hormonal therapy has been initiated or the malignancy has been surgically removed or treated with definitive radiotherapy.
Participant has received prior treatment with ASP2215 or other FLT3 inhibitors (with the exception of sorafenib and midostaurin used in first-line therapy regimen as part of induction, consolidation, and/or maintenance).
Participant has clinically significant abnormality of coagulation profile, such as disseminated intravascular coagulation (DIC).
Participant has had major surgery within 4 weeks prior to the first study dose.
Participant has radiation therapy within 4 weeks prior to the first study dose.
Participant has congestive heart failure New York Heart Association (NYHA) class 3 or 4, or Participant with a history of congestive heart failure NYHA class 3 or 4 in the past, unless a screening echocardiogram performed within 3 months prior to study entry results in a left ventricular ejection fraction that is ≥ 45%.
Participant requires treatment with concomitant drugs that are strong inducers of cytochrome P450 (CYP)3A.
Participants with mean of triplicate Fridericia-corrected QT interval (QTcF) > 450 ms at Screening based on central reading.
Participants with Long QT Syndrome at Screening.
Participants with hypokalemia and hypomagnesemia at Screening (defined as values below lower limit of normal [LLN]).
Participant requires treatment with concomitant drugs that are strong inhibitors or inducers of P glycoprotein (P-gp) with the exception of drugs that are considered absolutely essential for the care of the subject.
Participant requires treatment with concomitant drugs that target serotonin 5-hydroxytryptamine receptor 1 (5HT1R) or 5-hydroxytryptamine receptor 2B (5HT2BR) or sigma nonspecific receptor with the exception of drugs that are considered absolutely essential for the care of the subject.
Participant has an active uncontrolled infection.
Participant is known to have human immunodeficiency virus infection.
Participant has active hepatitis B or C, or other active hepatic disorder.
Participant has any condition which makes the Participant unsuitable for study participation.
Participant has active clinically significant GVHD or is on treatment with systemic corticosteroids for GVHD.
Participant has an FLT3 mutation other than the following: FLT3-ITD, FLT3-TKD/D835 or FLT3-TKD/I836.

Study & Design

Study Type: INTERVENTIONAL

Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Gilteritinib	gilteritinib	Participants received 120 mg dose (3 tablets of 40 mg) orally once a day in continuous 28-day cycles, at least 2 hours after or 1 hour before food. Gilteritinib treatment continued until participants met one of the treatment discontinuation criteria.
Salvage Chemotherapy	LoDAC (Low Dose Cytarabine)	Participants received chemotherapy in 28-day cycles. Participants on Low-Dose Cytarabine (LoDAC) received 20 mg of cytarabine twice daily by subcutaneous (SC) or intravenous (IV) injection for 10 days. Participants on azacitidine received 75 mg/m\^2 daily by SC or IV injection for 7 days. Participants on LoDAC or azacitidine treatment continued until they met discontinuation criteria. Participants on MEC chemotherapy received mitoxantrone 8 mg/m\^2 daily by IV for 5 days, etoposide 100 mg/m\^2 daily by IV for 5 days and cytarabine 1000 mg/m\^2 daily by IV for 5 days (days 1-5). Participants on FLAG-IDA chemotherapy received G-CSF 300 μg/m\^2 daily by SC/IV for 5 days (days 1-5), fludarabine 30 mg/m\^2 daily by IV for 5 days (days 2-6), cytarabine 2000 mg/m\^2 daily by IV for 5 days (days 2-6) and idarubicin 10 mg/m\^2 daily by IV for 3 days (days 2-4). Participants receiving MEC or FLAG-IDA received 1 cycle of therapy and were assessed for response on or after day 15.
Salvage Chemotherapy	MEC (Mitoxantrone, Etoposide, Cytarabine)	Participants received chemotherapy in 28-day cycles. Participants on Low-Dose Cytarabine (LoDAC) received 20 mg of cytarabine twice daily by subcutaneous (SC) or intravenous (IV) injection for 10 days. Participants on azacitidine received 75 mg/m\^2 daily by SC or IV injection for 7 days. Participants on LoDAC or azacitidine treatment continued until they met discontinuation criteria. Participants on MEC chemotherapy received mitoxantrone 8 mg/m\^2 daily by IV for 5 days, etoposide 100 mg/m\^2 daily by IV for 5 days and cytarabine 1000 mg/m\^2 daily by IV for 5 days (days 1-5). Participants on FLAG-IDA chemotherapy received G-CSF 300 μg/m\^2 daily by SC/IV for 5 days (days 1-5), fludarabine 30 mg/m\^2 daily by IV for 5 days (days 2-6), cytarabine 2000 mg/m\^2 daily by IV for 5 days (days 2-6) and idarubicin 10 mg/m\^2 daily by IV for 3 days (days 2-4). Participants receiving MEC or FLAG-IDA received 1 cycle of therapy and were assessed for response on or after day 15.
Salvage Chemotherapy	FLAG-IDA (Granulocyte-Colony Stimulating Factor (G-CSF), Fludarabine, Cytarabine, Idarubicin)	Participants received chemotherapy in 28-day cycles. Participants on Low-Dose Cytarabine (LoDAC) received 20 mg of cytarabine twice daily by subcutaneous (SC) or intravenous (IV) injection for 10 days. Participants on azacitidine received 75 mg/m\^2 daily by SC or IV injection for 7 days. Participants on LoDAC or azacitidine treatment continued until they met discontinuation criteria. Participants on MEC chemotherapy received mitoxantrone 8 mg/m\^2 daily by IV for 5 days, etoposide 100 mg/m\^2 daily by IV for 5 days and cytarabine 1000 mg/m\^2 daily by IV for 5 days (days 1-5). Participants on FLAG-IDA chemotherapy received G-CSF 300 μg/m\^2 daily by SC/IV for 5 days (days 1-5), fludarabine 30 mg/m\^2 daily by IV for 5 days (days 2-6), cytarabine 2000 mg/m\^2 daily by IV for 5 days (days 2-6) and idarubicin 10 mg/m\^2 daily by IV for 3 days (days 2-4). Participants receiving MEC or FLAG-IDA received 1 cycle of therapy and were assessed for response on or after day 15.
Salvage Chemotherapy	Azacitidine	Participants received chemotherapy in 28-day cycles. Participants on Low-Dose Cytarabine (LoDAC) received 20 mg of cytarabine twice daily by subcutaneous (SC) or intravenous (IV) injection for 10 days. Participants on azacitidine received 75 mg/m\^2 daily by SC or IV injection for 7 days. Participants on LoDAC or azacitidine treatment continued until they met discontinuation criteria. Participants on MEC chemotherapy received mitoxantrone 8 mg/m\^2 daily by IV for 5 days, etoposide 100 mg/m\^2 daily by IV for 5 days and cytarabine 1000 mg/m\^2 daily by IV for 5 days (days 1-5). Participants on FLAG-IDA chemotherapy received G-CSF 300 μg/m\^2 daily by SC/IV for 5 days (days 1-5), fludarabine 30 mg/m\^2 daily by IV for 5 days (days 2-6), cytarabine 2000 mg/m\^2 daily by IV for 5 days (days 2-6) and idarubicin 10 mg/m\^2 daily by IV for 3 days (days 2-4). Participants receiving MEC or FLAG-IDA received 1 cycle of therapy and were assessed for response on or after day 15.

Primary Outcome Measures

Name	Time	Method
Duration of Overall Survival (OS)	From randomization until the data cut-off date of 17 Sep 2018, median time of follow-up for OS was 17.8 months	Overall survival was defined as the time from the date of randomization until the date of death from any cause (death date - randomization date + 1). For a participant who was not known to have died by the end of study follow-up, OS was censored at the date of last contact (date of last contact - randomized date + 1). The date of last contact was the latest date that the participant was known to be alive by the cutoff date. The last contact date was derived for participants alive at the analysis cutoff date. Survival rate and 95% CI were estimated using the Kaplan-Meier method and the Greenwood formula.
Percentage of Participants With Complete Remission and Complete Remission With Partial Hematological Recovery (CR/CRh) in the Gilteritinib Arm	From randomization until the data cut-off date 04 Aug 2017, the 142 patients included in the primary analysis of CR/CRh rate were followed up at least 112 days	The CR/CRh rate was defined as the number of participants who achieved either CR or CRh at any of the postbaseline visits divided by the number of participants in the analysis population.

Secondary Outcome Measures

Name	Time	Method
Duration of Event-Free Survival (EFS)	From randomization until the data cut-off date of 17 Sep 2018, median time of follow-up for OS was 17.8 months	EFS was defined as the time from the date of randomization until the date of documented relapse (excluding relapse after PR), treatment failure or death from any cause within 30 days after the last dose of study drug, whichever occurred first (earliest of \[relapse date, treatment failure date, death date\] - randomization date + 1). If a participant experienced relapse or death within 30 days after the last dose of study drug, the participant was defined as having an EFS event related to either "relapse" or "death", and the event date was the date of relapse or death. For a participant who was not known to have had a relapse or treatment failure or death event, EFS was censored at the date of last relapse-free disease assessment (last relapse-free disease assessment date - randomization date + 1). Data was estimated based on Kaplan-Meier estimates.
Percentage of Participants With Complete Remission (CR) Rate	From randomization until the data cut-off date of 17 Sep 2018, all participants included in the primary analysis of CR rate were followed up at least 6 months	The CR rate was defined as the number of participants who achieved the best response of CR divided by the number of participants in the analysis population.
Duration of Leukemia-Free Survival (LFS)	From randomization until the data cut-off date of 17 Sep 2018, median time of follow-up for OS was 17.8 months	The LFS was defined as the time from the date of first CRc until the date of documented relapse (excluding relapse from PR) or death for participants who achieved CRc (relapse date or death date - first CRc disease assessment date + 1). For a participant who was not known to have relapsed or died, LFS was censored on the date of last relapse-free disease assessment date (last relapse-free disease assessment date - first CRc disease assessment date + 1). For a participant who was not known to have relapsed or died, LFS was censored on the date of last relapse-free disease assessment date (last relapse-free disease assessment date - first CRc disease assessment date + 1).
Duration of Remission	From randomization until the data cut-off date of 17 Sep 2018, median time of follow-up for OS was 17.8 months	Duration of remission included duration of composite complete remission (CRc), duration of complete remission (CR)/ complete remission with partial hematologic recovery (CRh), duration of CRh, duration of CR and duration of response (CRc + partial remission (PR). The duration of response was defined as the time from the date of either first CRc or PR until the date of documented relapse (i.e., the date of first NR after CRc or PR) for participants who achieved CRc or PR (relapse date - first CRc or PR disease assessment date + 1). Participants who died without report of relapse were considered nonevents and censored at their last relapse-free disease assessment date (last relapse-free disease assessment date - first CRc or PR disease assessment date + 1). Other participants who did not relapse during the study were considered nonevents and censored at the last relapse-free assessment date. Duration of CR was only applicable to participants with best overall response of CR.
Percentage of Participants With Composite Complete Remission (CRc Rate)	From randomization until the data cut-off date of 17 Sep 2018, median time of follow-up for OS was 17.8 months	CRc rate was defined as the number of participants who achieved the best response of CRc (CR,complete remission with incomplete platelet recovery (CRp) or complete remission with incomplete hematologic recovery (CRi) divided by the number of participants in the analysis population.
Percentage of Participants Who Underwent Hematopoietic Stem Cell Transplant	From randomization until the data cut-off date of 17 Sep 2018, median time of follow-up for OS was 17.8 months	Transplantation rate is defined as the percentage of participants undergoing Hematopoietic stem cell transplant (HSCT) during the study period.
Change From Baseline in Brief Fatigue Inventory (BFI)	Baseline and cycle 1, day 8 and cycle 2 day 1 (up to data cut off date of 17 Sep 2018)	The Brief Fatigue Inventory (BFI) is a screening tool designed to assess the severity and impact of fatigue on daily functioning of participants with cancer during the 24 hours. There are 9 items on the scale. The first three questions ask participants to rate their fatigues on a scale from 0 (no fatigue) - 10 (as bad as you can imagine), with higher scores indicating worse outcome. The remaining six questions ask participants to rate how much fatigue has interfered with their daily activities on a scale from 0 (Does not interfere) to 10 (Completely interferes). A global fatigue score can be obtained by averaging all the items on the BFI. The global BFI score will be calculated only if at least 5 of the 9 items are answered. A higher BFI fatigue score indicates worse outcome.
Percentage of Participants With Complete Remission (CR) With Partial Hematological Recovery (CRh)	From randomization until the data cut-off date of 17 Sep 2018, median time of follow-up for OS was 17.8 months	CRh rate was defined as the number of participants who achieved CRh at any of the postbaseline visits and did not have a best response of CR divided by the number of participants in the analysis population.
Percentage of Participants Who Achieved Transfusion Conversion and Maintenance	From randomization until the data cut-off date of 17 Sep 2018, median treatment duration for gilteritinib was (126.00 [4.0, 885.0]) days versus salvage chemotherapy 28.0 [5.0, 217.0] days)	Transfusion conversion \& maintenance rate was defined for gilteritinib arm. Participants were classified as transfusion independent if there were no RBC or platelet transfusions within 28 days prior to the first dose to 28 days after the first dose; otherwise they were classified as transfusion dependent at baseline. Participants were considered independent postbaseline if they had 1 consecutive 8 week period without any RBC or platelet transfusion from 29 days after the first dose until the last dose date. For participants who were on treatment ≤ 4 weeks or \> 4 weeks but \< 12 weeks and there was no RBC or platelet transfusion within postbaseline period, they were considered not evaluable; otherwise, they were considered postbaseline transfusion dependent. Transfusion conversion rate was defined for participants who had evaluable postbaseline transfusion status. Transfusion status (independent vs. dependent) at baseline and postbaseline was reported in a 2 by 2 contingency table.
Number of Participants With Adverse Events	From first dose of study drug up to 30 days after the last dose of study drug (median treatment duration for gilteritinib was (126.00 [4.0, 885.0]) days versus salvage chemotherapy 28.0 [5.0, 217.0] days)	A treatment-emergent adverse event (TEAE) was defined as an AE observed after starting administration of the study drug (gilteritinib or salvage chemotherapy). If the AE occurred on day 1 and the onset check box was marked "Onset after first dose of study drug" or the onset check box was left blank, then the AE was considered treatment emergent. If the AE occurred on day 1 and the onset check box was marked "Onset before first dose of study drug", then the AE was not considered treatment emergent. Majority of salvage chemotherapy participants finished the study by cycle 2 of treatment, the duration of exposure was longer in the gilteritinib arm compared with the salvage chemotherapy arm (126.00 \[4.0, 885.0\] days versus 28.0 \[5.0, 217.0\] days). The NCI-CTCAE is defined as National Cancer Institute-Common Terminology Criteria for Adverse Events.

Trial Locations

Locations (126): Site PL48004
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Wroclaw, Poland
Site US10044
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Cleveland, Ohio, United States
Site US10034
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Boston, Massachusetts, United States
Site US10085
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Boston, Massachusetts, United States
Site US10057
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Minneapolis, Minnesota, United States
Site US10024
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Durham, North Carolina, United States
Site US10073
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San Francisco, California, United States
Site US10063
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Nashville, Tennessee, United States
Site US10087
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Detroit, Michigan, United States
Site US10058
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Oklahoma City, Oklahoma, United States
Site US10006
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Chicago, Illinois, United States
Site US10027
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Hackensack, New Jersey, United States
Site US10001
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Buffalo, New York, United States
Site US10012
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Los Angeles, California, United States
Site US10084
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Columbus, Ohio, United States
Site US10081
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Atlanta, Georgia, United States
Site BE32002
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Yvoir, Belgium
Site US10037
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New York, New York, United States
Site US10023
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Lebanon, New Hampshire, United States
Site US10046
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Syracuse, New York, United States
Site US10072
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New York, New York, United States
Site US10010
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Philadelphia, Pennsylvania, United States
Site DE49009
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Dresden, Germany
Site IL97201
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Ashkelon, Israel
Site IL97209
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Haifa, Israel
Site JP81004
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Shinagawa-ku, Tokyo, Japan
Site JP81025
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Kyoto, Japan
Site KR82003
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Jeollanam-do, Korea, Republic of
Site JP81018
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Kobe, Hyogo, Japan
Site JP81009
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Isehara, Kanagawa, Japan
Site JP81005
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Chuo-ku, Tokyo, Japan
Site JP81008
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Nagasaki, Japan
Site JP81024
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Okayama, Japan
Site JP81011
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Osaka, Japan
Site CA15015
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Toronto, Ontario, Canada
Site FR33008
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Toulouse, France
Site US10011
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Birmingham, Alabama, United States
Site IL97210
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Jerusalem, Israel
Site US10035
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Milwaukee, Wisconsin, United States
Site US10076
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Orange, California, United States
Site US10022
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Boston, Massachusetts, United States
Site US10075
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Westwood, Kansas, United States
Site US10005
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Baltimore, Maryland, United States
Site US10077
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New Brunswick, New Jersey, United States
Site US10008
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New York, New York, United States
Site US10013
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New York, New York, United States
Site US10041
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Hershey, Pennsylvania, United States
Site US10080
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Philadelphia, Pennsylvania, United States
Site CA15004
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Edmonton, Alberta, Canada
Site CA15001
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Hamilton, Ontario, Canada
Site CA15003
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Montreal, Quebec, Canada
Site FR33013
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Brest, France
Site DE49003
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Marburg, Germany
Site FR33002
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Le Chesnay Cedex, France
Site FR33010
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Lille, France
Site FR33014
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Rennes, France
Site FR33009
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Pessac, France
Site DE49002
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Munchen, Germany
Site DE49011
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Leipzig, Germany
Site DE49010
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Tubingen, Germany
Site IL97203
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Jerusalem, Israel
Site IL97206
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Petah Tikva, Israel
Site IT39005
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Bologna, Italy
Site IL97208
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Rehovot, Israel
Site IT39001
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Milan, Italy
Site IT39010
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Brescia, Italy
Site IT39004
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Palermo, Italy
Site IT39002
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Varese, Italy
Site JP81002
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Nagoya, Aichi, Japan
Site JP81026
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Yoshida-gun, Fukui, Japan
Site JP81010
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Narita, Chiba, Japan
Site JP81016
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Sapporo, Hokkaido, Japan
Site JP81017
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Tsukuba, Ibaraki, Japan
Site JP81006
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Yokohama, Kanagawa, Japan
Site JP81007
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Kurashiki, Okayama, Japan
Site JP81012
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Sendai, Miyagi, Japan
Site JP81014
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Osakasayama, Osaka, Japan
Site IT39011
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Pavia, Italy
Site IT39007
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Roma, Italy
Site JP81020
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Kawagoe, Saitama, Japan
Site JP81027
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Shimotsuke, Tochigi, Japan
Site JP81022
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Shinjuku-ku, Tokyo, Japan
Site JP81023
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Akita, Japan
Site JP81021
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Aomori, Japan
Site JP81013
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Kumamoto, Japan
Site KR82009
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Goyang, Korea, Republic of
Site KR82005
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Suwon-si, Gyeonggi-do, Korea, Republic of
Site KR82010
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Busan, Korea, Republic of
Site KR82007
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Seoul, Korea, Republic of
Site KR82002
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Seoul, Korea, Republic of
Site KR82004
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Seoul, Korea, Republic of
Site KR82001
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Seoul, Korea, Republic of
Site KR82008
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Seoul, Korea, Republic of
Site PL48002
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Gdansk, Poland
Site KR82011
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Seoul, Korea, Republic of
Site ES34010
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Barcelona, Spain
Site ES34011
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Barcelona, Spain
Site ES34012
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Barcelona, Spain
Site ES34009
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Badalona, Spain
Site ES34016
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Girona, Spain
Site TW88609
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Taichung City, Taiwan
Site ES34017
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Valencia, Spain
Site ES34014
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Salamanca, Spain
Site ES34005
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L'Hospitalet de Llobregat, Spain
Site TW88604
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Kaohsiung, Taiwan
Site TW88608
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Taichung, Taiwan
Site TR90004
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Ankara, Turkey
Site TW88601
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Tainan, Taiwan
Site TW88610
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Taipei, Taiwan
Site GB44014
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Bournemouth, United Kingdom
Site GB44013
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Harrow, United Kingdom
Site TW88602
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Taipei, Taiwan
Site TW88611
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Taipei, Taiwan
Site TW88605
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Taoyuan, Taiwan
Site TR90001
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Ankara, Turkey
Site GB44015
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Plymouth, United Kingdom
Site GB44003
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Manchester, United Kingdom
Site TW88606
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Kaohsiung, Taiwan
Site TW88603
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Taipei, Taiwan
Site PL48005
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Opole, Poland
Site US10067
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New Haven, Connecticut, United States
Site US10014
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Charleston, South Carolina, United States
Site US10074
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Louisville, Kentucky, United States
Site US10078
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Winston-Salem, North Carolina, United States
Site US10045
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Gainesville, Florida, United States
Site US10048
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New Orleans, Louisiana, United States