sterile water and normal saline in PC
- Conditions
- Calculus of kidney with calculus of ureter.Calculus of kidney with calculus of ureter
- Registration Number
- IRCT201212291323N5
- Lead Sponsor
- Deputy of information and Research , Yasuj University of Medical Science
- Brief Summary
Comparison of the Efficacy and Adverse Effects of Sterile Water with<br /> Normal Saline in Percutaneous Nephrolithotomy (PCNL)<br /> Sadrollah Mehrabi1,<br /> Samira Nazari2,<br /> Hammidreza Ghafarian Shirazi3,<br /> Abolghasem Hadinia4,<br /> 1 Professor, Social Determinants of Health Research Center, Yasuj University of Medical Sciences, Yasuj, Iran<br /> 2 General Practitioner, Students Research committee, Yasuj University of Medical Sciences, Yasuj, Iran<br /> 3 Assistant Professor, Social Determinants of Health Research Center, Yasuj University of Medical Sciences, Yasuj, Iran<br /> 4 Lecturer, Cellular and Molecular Research Center, Yasuj University of Medical Sciences, Yasuj, Iran<br /> (Received July 14, 2012; Accepted December 15, 2012)<br /> Abstract<br /> Background and purpose: The irrigation fluid that routinely used during percutaneous nephrolithotomy<br /> (PCNL) has systemic absorption. The aim of this study was comparing the efficacy and adverse effects of sterile<br /> water and normal saline as an irrigant fluid in PCNL.<br /> Materials and methods: Ninety four older than 18 years old patients with renal or upper ureteral stones<br /> that were candidate for PCNL randomly allocated in two groups. Patient with American Society of Anesthesiologists<br /> (ASA) score 3 and 4 and history of hemolysis excluded from study. From all patient, serum base laboratory and<br /> serum electrolyte was taken. Then, under spinal anesthesia PCNL was done with fluoroscope guidance in standard<br /> method with use of normal saline in first group. In second group, PCNL with fluoroscope guidance in standard<br /> method with use of sterile water was done, too. Preoperative, intraoperative and postoperative variables such as<br /> serum sodium, potassium and haptoglobin, cost and duration of surgery, pulmonary and cardiovascular<br /> complications compared between two groups. Data was collected and analyzed using chi-square and paired -t tests.<br /> Results: Demographic characteristics, operation time, serum electrolytes and volume of irrigation fluid were<br /> similar in two groups. Mean postoperative haptoglobin in group one and two were 1.15 ± 0.38 and 1.29 ± 0.53 mg/dl<br /> respectively (P = 0.263). Mean cost in group one and two were 117,234 and 25,400 Rial, respectively and there were<br /> no cardiovascular and pulmonary complications.<br /> Conclusion: Use of sterile water as an irrigation fluid in PCNL is inexpensive, safe and more available and<br /> have not more complications in compare with normal saline that can be used as an alternative fluid in PCNL<br /> operation.<br /> Keywords: Sterile water, normal saline, PC
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 94
inclusion and exclusion criteria are includes (Age>18 years old ,patients with renal or upper ureteral stone larger than 20 millimeter candidate for percutaneous nephrolithotripsy ,
Exclusion criteria: patients with urinary stone younger than 18 years old ,patients with azotemia.uncontrolled coagulopathy,active infection,history of hemolysis,any contraindication for general or spinal anesthesia,COPD,ASA score 3 and 4 )
Not provided
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Cheke of serum electrolytes and hemolysis in percutaneous nephrolithotripsy. Timepoint: Before operation and 6 hour after operation. Method of measurement: checking Na,K,and serum haptoglubin before and 6 hour operation.
- Secondary Outcome Measures
Name Time Method Development of any cardiovascular or pulmonary complications. Timepoint: during operation to one week later. Method of measurement: report of patients and observation with examination lung and heart of of patients pulse oximetery during operation,and check of lower limb pulses.