Assessement of Viral Shedding Duration After a Respiratory Tract Infection in Oncology and Hematology Patients
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 44
- 试验地点
- 2
- 主要终点
- Nasal carriage of virus after a viral respiratory tract infection
研究概览
简要总结
The purpose of this study is to assess the duration of the viral shedding in hematology and oncology patients after a respiratory tract viral infection. This duration has not been much studied in that population whereas it is probably longer than that in immunocompetent patients. Thereby it may be a source of transmission amongst these immunocompromised patients.
详细描述
The development of multiplex polymerase chain reaction (PCR) tests has greatly improved the diagnosis of respiratory tract viral infections by increasing its sensitivity and the diversity of viral species detected. However, there are few data concerning respiratory tract viral infections amongst hematology and oncology patients. Especially, the duration of viral shedding following an infection has not been much studied whereas it is a source of inter-individual transmission between immunocompromised patients who are more likely to develop severe disease.
Studies conducted so far concerned mainly hematology patients. They have shown that viral carriage could last up to one month and a half in some patients with hematological malignancy.
The aim of this study is to determine the duration of the viral shedding in patients from hematology and oncology units after a respiratory tract viral infection for the ten main viruses involved in order to better manage these infections and to better prevent their transmission.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Prevention
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patient with solid organ cancer or haematological malignancy with or without chemotherapy
- •Having symptoms of upper and/or lower respiratory tract infection
- •Virus detected by PCR in nasal sample
- •Signature of consent
排除标准
- •Hematological stem cell and solid organ recipients
- •No health insurance
- •protected people
结局指标
主要结局
Nasal carriage of virus after a viral respiratory tract infection
时间窗: Up to 1 year
Iterative nasal swab to assess the duration of that carryiage
次要结局
- nosocomial transmission of respiratory tract viral infection(2 years)
- delay of chemotherapy due to respiratory infection(2 years)
- Prevalence of viral coinfections(2 years)
- transmission of respiratory tract viral infections by relatives(2 years)
- TTV viral load as a marker of immunodepression in oncology and hematology patients(2 years)
- Correlation between TTV viral load and duration of viral shedding and severity of respiratory tract infection(2 years)
- effect of influenza vaccine on viral shedding(2 years)
- risk factors to do severe form of respiratory tract infection(2 years)
- Prevalence of upper and lower respiratory tract infections(2 years)
- Prevalence of bacterial coinfections(2 years)
- respiratory complications due to respiratory tract viral infections(2 years)
- extra-pulmonary symptoms due to respiratory tract viral infections(2 years)
- survival after a respiratory tract viral infection(30 days)