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Clinical Trials/NCT07621978
NCT07621978Not yet recruitingNot Applicable

Feasibility and Potential Efficacy of High-intensity Gait Training in Individuals With Cerebellar Damage

Indiana University0 sites20 target enrollmentStarted: June 15, 2026Last updated:
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Trial Snapshot

Phase
Not Applicable
Status
Not yet recruiting
Enrollment
20
Study OverviewStudy DesignEligibility CriteriaInvestigatorsRecords & IdentifiersSimilar Trials

Study Overview

Brief Summary

The goal of this study is to evaluate the feasibility and potential preliminary efficiency of high-intensity training focused on stepping in variable contexts as compared to conventional training in individuals with cerebellar disease

Detailed Description

The goal of this study is to evaluate the feasibility and potential preliminary efficiency of high-intensity training focused on stepping in variable contexts as compared to conventional training in individuals with cerebellar disease

Study Design

Study Type
Interventional
Allocation
Randomized
Intervention Model
Crossover
Primary Purpose
Treatment
Masking
Single (Outcomes Assessor)

Masking Description

Assessments will be performed by blinded raters unaware of group assignment.

Eligibility Criteria

Ages
18 Years to 85 Years (Adult, Older Adult)
Sex
All
Accepts Healthy Volunteers
No

Inclusion Criteria

  • •Ages 18-85
  • •>6 months following brain injury or diagnosis of cerebellar dysfunction
  • •A total score of > 4 on items 5-8 on the SARA for the ipsilateral limb
  • •Ability to ambulate 10 m at self-selected gait speeds (SSV) <1.2 m/s with no greater than minimal physical assistance permitted for postural stability only, but with below knee bracing and/or assistive device as needed
  • •Weight < 350 pounds
  • •Able to follow 1-step command
  • •Medical clearance to participate

Exclusion Criteria

  • •Uncontrolled cardiopulmonary or metabolic disease that limits exercise participation, active heterotopic ossification, recurrent history of lower extremity fractures, previous orthopedic or other peripheral or central neurologic injury that may impair locomotor activities
  • •Currently participating in other physical therapy
  • •>50 units of Botox within the past three months in the lower extremity OR in the lower extremity, but above the knee if the participant wears an ankle-foot-orthosis
  • •Individuals deemed not stable between Pre-Baseline Testing and Baseline Testing

Investigators

Sponsor Class
Other
Responsible Party
Principal Investigator
Principal Investigator

George Hornby

Professor

Indiana University

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