Influence of Meal Skipping on Macronutrient Oxidation and Glucose Metabolism Under Isocaloric Conditions

Not Applicable

Completed

• Conditions: Healthy
• Interventions: Behavioral: Dinner skipping; Behavioral: Breakfast skipping

• Registration Number: NCT02635139
• Lead Sponsor: University of Hohenheim

Brief Summary

Aim of the study is to investigate the impact of meal skipping (breakfast or dinner skipping) on the regulation of glucose metabolism and macronutrient balance (protein/fat/carbohydrate intake vs. -oxidation). An isoenergetic diet with 3 conventional meals (breakfast, lunch, dinner) serves as a control.

Detailed Description

The duration of the study is 7 days including 3 days with controlled diet and 4 days (including 5 nights) in a metabolic chamber at the Institute of Nutritional Medicine at the University of Hohenheim.

The study phase in the metabolic chamber consists of (i) 1 day with 3 meals/day = baseline day, (ii) 1 day with breakfast skipping, (iii) 1 day with dinner skipping, (iv) 1 washout day where the subjects leave the chamber between 7 a.m. until 7 p.m..

Beginning on the 3rd study day macronutrient and energy intake as well as the fasting periods are kept constant. To achieve comparable conditions the washout day is setted before the baseline day.

Study Timeline

• Study Start: 2015-12
• Study First Submitted: 2015-12-13
• Study First Submitted QC: 2015-12-16
• Study First Posted: 2015-12-18
• Primary Completion: 2016-07
• Study Completion: 2016-10
• Status Verified: 2017-04
• Last Update Submitted: 2017-04-22
• Last Update Posted: 2017-04-25

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 17

Inclusion Criteria

• healthy
• not obese (BMI<30)

Exclusion Criteria

• food allergy
• smoking
• alternative nutrition habits
• chronic disease
• regular medication intake
• claustrophobia

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
Dinner Skipping	Dinner skipping	Effect of dinner skipping on metabolism
Breakfast Skipping	Breakfast skipping	Effect of breakfast skipping on metabolism

Primary Outcome Measures

Name	Time	Method
Regulation of glucose metabolism (substrate oxidation and insulin sensitivity)	1 day

Secondary Outcome Measures

Name	Time	Method
cardio vascular risk (lipid profile, arterial stiffness, autonomic function)	1 day
Actigraphy-assessed sleep quality	1 day

Trial Locations

Locations (1)

Institute of Nutritional Medicine, University of Hohenheim; 🇩🇪 Stuttgart, Germany