IVF/ICSI Outcomes of OCP Plus GnRH Agonist Protocol Versus OCP Plus GnRH Antagonist Fixed Protocol in Women With PCOS
试验速览
- 阶段
- 不适用
- 状态
- 终止
- 发起方
- 入组人数
- 300
- 试验地点
- 2
- 主要终点
- Ongoing pregnancy rates
研究概览
简要总结
Outcomes of IVF/ICSI cycles of women with PCOS undergoing Gonadotropin Releasing Hormone (GnRH) agonist and GnRH Antagonist fixed protocol.
详细描述
Women with PCOS undergoing IVF/ICSI cycles will be evaluated by two different protocols. One arm of the study includes oral contraceptive plus GnRH agonist protocol with 150 IU FSH (standard dose) and second arm includes oral contraceptive plus GnRH Antagonist with 150 IU FSH dose and fixed 6th day starting of GnRH Antagonist.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Single Group
- 盲法
- Single (Investigator)
入排标准
- 年龄范围
- 20 Years 至 35 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •PCOS women undergoing ICSI cycles
- •All women will be administered 150 IU rec FSH
排除标准
- •Women having other endocrinopathies
- •women older than 35
- •third IVF/ICSI cycles
- •previous and current use of metformin
结局指标
主要结局
Ongoing pregnancy rates
时间窗: March 2009 to June 2011
Ongoing pregnancy rates measured in OCP plus GnRH Agonist and OCP plus GnRH Antagonist cycles in women with PCOS
clinical pregnancy rate
时间窗: from march 2009 to july 2011
To evaluate the clinical pregnancy rates of both study arms
Total gonadotropin use
时间窗: From march 2009 to June 2011
Total gonadotropin use of both study arms
次要结局
- OHSS rates(from march 2009 to july 2011)
- Total ongoing pregnancy rate(from march 2009 to june 2011)
研究者
Bulent Haydardedeoglu
IVF/ICSI Outcomes of OCP Plus GnRH Agonist Protocol Versus OCP Plus GnRH Antagonist Fixed Protocol in Women With PCOS: A Randomized Controlled Trial
Baskent University