Treatment of Periodontal bony defect using various bone graft
- Conditions
- Chronic periodontitis,systemically healthy individuals diagnosed with periodontal osseous intrabony defect on clinical and radiographic evaluation with Probing Depth more than 4 mm and an intrabony component more than 3 mm
- Registration Number
- CTRI/2023/09/057332
- Lead Sponsor
- Sardar Patel Post Graduate of Dental and Medical Sciences
- Brief Summary
Periodontitis is an inflammatory disease of the periodontium which elicits an immune response resulting in the loss of supporting structures of the teeth. The bone loss which is induced by periodontitis i.e. osseous defects occur either single or in different combination forms. Intrabony osseous defect is defined as a “periodontal defect within the bone surrounded by one, two or three bony walls or a combinationâ€. Treatment with grafting modalities, xenogenic or alloplastic osteoconductive materials, such as bovine bone-derived mineral, coralline calcium carbonate, calcium-layered composite of poly-methyl-methacrylate and poly-hydroxyl-ethyl-methacrylate, hydroxyapatite, bioactive glass and tricalcium phosphate are options. Bone graft is use to fill the defect, supporting and promoting new bone formation, through its use as mechanical scaffold and provides a structure for new cells to form new bone growth in the healing process. Hydroxyapatite cement (HAC) has been extensively studied as the bone grafting material in periodontal regeneration. The biocompatibility, osteoconductive nature and resorptive properties of HAC suggest it has potential to function as a successful bone substitute material. biocomposites(BC) such as beta tricalcium phosphate and calcium sulfate represent a unique bi-phasic composition with a negative charged surface. This property stimulates bone cell activity by harnessing key proteins, osteoblast adhesion and proliferation.In this study thirty patients diagnosed with periodontitis showing pocket depth >5mm and radiographic evidence of vertical/ angular bony defects will be selected from Department of Periodontology, SPPGIDMS, Lucknow and will be allocated randomly into two groups. Groups A (biocomposites + open flap debridement) and Group B (hydroxyapatite cement + open flap debridement). Clinical periodontal parameters like probing pocket depths (PPD), clinical attachment level (CAL), plaque index (PI), gingival index (GI), and radiographic assessment of the defect will be evaluated at baseline, 3 and 6 months after treatment.The present study will evaluate and compare the efficacy of injectable biocomposites and HAC in periodontal regeneration. We anticipate that this will enable improved treatment of periodontal osseous defects.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Not Yet Recruiting
- Sex
- All
- Target Recruitment
- 30
1.Patient age between16-40 years diagnosed with periodontitis 2.Teeth selection All the teeth diagnosed with periodontal osseous intrabony defect Two or three wall defect on clinical and radiographic evaluation 3.PD more than or equal to 4 mm and an intrabony component more than or equal to 3 mm 4.The depth of the intraosseous component of the defect was evaluated clinically and radiographically during the screening phase but it had to be confirmed during surgery 5.Systemically healthy patients 6.Patients with established willingness and ability to perform adequate oral hygiene.
- Heavy smoking (more than 10 cigarettes) 2.
- Presence of underlying medical conditions such as immunosuppression or diabetes pregnancy and medically compromised conditions that would put the patient at risk for periodontal surgery.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The outcome expected will be to compare the Baseline | 3 months | 6 months regenerative capacity of injectable biocomposites & granular form of Hydroxyapatites in Baseline | 3 months | 6 months an adjunct with OFD in treatment of intrabony defects. Baseline | 3 months | 6 months
- Secondary Outcome Measures
Name Time Method the secondary outcome is radiographic evaluation of the bone fill & bone density post operative in treatments of intrabony defects. 6 months post operative
Trial Locations
- Locations (1)
SARDAR PATEL POST GRADUATE INSTITUTE OF DENTAL AND MEDICAL SCIENCES
🇮🇳Lucknow, UTTAR PRADESH, India
SARDAR PATEL POST GRADUATE INSTITUTE OF DENTAL AND MEDICAL SCIENCES🇮🇳Lucknow, UTTAR PRADESH, IndiaDR HIMANI TRIPATHIPrincipal investigator9792320403tripathihimani260@gmail.com