Does allopurinol reduce the size of the right side of the heart in patients who have chronic lung disease and high pressure in the blood vessels supplying the lungs?

Not Applicable

Completed

• Conditions: Circulatory System; Pulmonary hypertension and chronic obstructive pulmonary disease / interstitial lung disease

• Registration Number: ISRCTN11081180
• Lead Sponsor: HS Tayside - University of Dundee

Brief Summary

2020 results in https://pubmed.ncbi.nlm.nih.gov/32904701/ (added 29/12/2020)

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2015-02-17
• Study Completion: 2017-06-16
• Last Update Posted: 11 January 2021

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 71

Inclusion Criteria

1. Aged 18 years or over
2. Previously diagnosed with COPD or ILD
3. Screening echocardiography based diagnosis of PH as indicated by RVSP >25 mmHg, and/or PAT <110 m/s2 and/or RVM >5.5 mm
4. Stable lung disease medication for at least 2 weeks prior to consent
5. Women of child bearing potential must agree to scheduled pregnancy testing prior to and during study treatment period and to use an appropriate method of contraception if sexually active

Exclusion Criteria

1. Documented allergy or intolerance to allopurinol
2. Objection to taking capsules made from animal-sourced gelatine
3. Left Ventricular Ejection Fraction <45% on echocardiography screening
4. Severe aortic stenosis on echocardiography (screening)
5. Already had gout or currently taking allopurinol
6. Severe hepatic disease
7. Renal disease; CKD class 3B or greater
8. Taking prohibited medication; azathioprine, 6 mercaptopurine, or theophylline
9. Malignancy (receiving active treatment) or other life threatening diseases
10. Pregnant or lactating
11. Women unwilling to agree to use an appropriate method of contraception during the
study treatment period if sexually active
12. Any contraindication to MRI (claustrophobia, metal implants)
13. Patients who have participated in any other clinical trial of an investigational medicinal product within the previous 30 days will be excluded
14. Any other considered by a study physician to be inappropriate for inclusion

Study & Design

• Study Type: Interventional
• Study Design: Not specified