The assessment of the effect of omega-3 supplementation on serum interleukin-6, alpha tumor necrosis factor and depression status in bipolar patients

Phase 3

Conditions: Bipolar disorder.
Bipolar disorder, current episode depressed, mild or moderate severity
F31.3

Registration Number: IRCT20211220053469N1

Lead Sponsor: Zahedan University of Medical Sciences

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Complete

Sex: All

Target Recruitment: 60

Inclusion Criteria

The involvement with bipolar disease
Patients with minimum six months after onset of disease
Informed and freely consent for participation in the design by patient and family members.
The lack of receiving omega-3 supplement several months before of participation in the study
The lack of programmed surgery in three months future
The lack of consumption of drugs interfering with omega-3 such as anticoagulant drugs
The lack of high blood pressure
The lack of alcohol and drugs

Exclusion Criteria

The change in drug dose and type
Sensitive reaction against omega-3
The consumption of lesser than 80% supplement
The involvement with inflammatory and infectious diseases
Withdrawal of the study for any reason

Study & Design

Study Type: interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Mean of interleukin 6. Timepoint: At the beginning of the study (before the intervention) and 60 days after the start of omega-3 supplementation. Method of measurement: Commercial Kit / ELISA.;Mean of alpha tumor necrosis factor. Timepoint: At the beginning of the study (before the intervention) and 60 days after the start of omega-3 supplementation. Method of measurement: Commercial Kit / ELISA.;Depression score on the Hamilton questionnaire. Timepoint: At the beginning of the study (before the intervention) and 60 days after the start of omega-3 supplementation. Method of measurement: Hamilton questionnaire.

Secondary Outcome Measures