Reversal of Neuromuscular Blockade During the General Anaesthesia
试验速览
- 阶段
- 不适用
- 状态
- 进行中（未招募）
- 入组人数
- 120
- 试验地点
- 1
- 主要终点
- Incidence of postrecovery relaxation
研究概览
简要总结
There are individual reports indicating that after the reversal of nondepolarizing neuromuscular blockade with neostigmine, some patients starts to relax spontaneously again after the tof ratio has already recovered to the safe level (>90%).
The mechanism behind this in not well understood, and the incidence of the phenomenon is unclear. In this study the investigators try to determine the incidence of the aforementioned postrecovery relaxation.
详细描述
There are individual reports indicating that after the reversal of nondepolarizing neuromuscular blockade with neostigmine, some patients start to relax spontaneously again after the tof ratio has already recovered to the safe level (90%). The mechanism behind this in not well understood and the incidence of the phenomenon is unclear.
The aim of this study is to monitor the reversal of rocuronium induced neuromuscular blockade with neostigmine. The neuromuscular blockade is monitored with train of four stimulations using electromyography. After the reversal agent is given and train of four ratio has recovered to the level of 90%, the neuromuscular blockade is monitored another 30min to see if tof ratio starts to spontaneously fall again under the 90%. If aforementioned postrecovery relaxation happens, the investigators are able to calculate the incidence of the phenomenon.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Elective surgery requiring general anaesthesia
- •Surgery is assumed to last more than 45 minutes
- •Body mass index less than 35kg/ m²
排除标准
- •Disease of central nervous system
- •Trauma of central nervous system
- •Disease affecting peripheral nervous system
- •Medication affecting peripheral nervous system
研究组 & 干预措施
Study group
Single arm and everyone gets the same treatment according the protocol
干预措施: Neostigmine, Combinations (Drug)
结局指标
主要结局
Incidence of postrecovery relaxation
时间窗: 30 minutes
Number of patients (if any) with postrecovery relaxation divided by a number of all patients
次要结局
未报告次要终点