Barley Beta-glucan, Glycemic Control, and Appetite
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 16
- 试验地点
- 2
- 主要终点
- Postprandial glycemic response
研究概览
简要总结
Novel barley varieties high in the soluble fiber β-glucan have the capacity to improve population health through improving glycemic control. Sweetened and unsweetened wholegrain barley foods were tested in a randomized, controlled, crossover human clinical trial to assess impact on postprandial appetite and food intake.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Prevention
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 18 Years 至 50 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •18-50 years of age
- •Body Mass Index (BMI) values of 18.5-40.0 kg/m2
- •Normal fasting blood glucose (<100 mg/dL)
排除标准
- •Use of medications known to be associated with weight change (e.g., beta-blockers)
- •Use of steroid pills or shots such as prednisone or cortisone
- •Use of nicotine
- •Weight change of ten or more pounds in the last three months
- •Major daily variation in physical activity (e.g., athletes in training)
- •History of extensive small bowel surgery or surgery to treat obesity
- •History of heart attack, stroke, or bypass
- •History of cancer within the last five years (exception: non-melanoma skin cancer)
- •Recent or current medical diagnosis or medical treatment that would alter appetite, energy needs, satiety, and/or could impact the results of the trial
- •Medical diagnoses of diabetes, cardiovascular disease, high levels of blood lipids, asthma, cold, and flu (exception: hypertension, if treated with medication prescribed more than three months prior to the screening activity)
- •Fear of blood or needles
- •Dietary restrictions that would interfere with consuming test foods (e.g., gluten intolerance, vegan, corn syrup allergy)
- •Following a weight modification diet
- •Sensitive to food textures present in the test foods
- •Following personal schedules that would not permit attendance at all scheduled testing sessions
- •Unable to comprehend the nature of the trial or instructions
- •Unable to understand English sufficiently to complete the trial
结局指标
主要结局
Postprandial glycemic response
时间窗: 4 hours
Blood glucose measured every 15 minutes post-preload ingestion
Subjective appetite
时间窗: 4 hours
Self-reported appetite measured using Visual Analogue Scale (VAS) every 15 minutes post-preload ingestion
Food intake
时间窗: 30 minutes
Food intake at a 16-item ad libitum test meal served 4 hours post-preload ingestion
次要结局
未报告次要终点
研究者
Martine Perrigue
Assistant Professor, Nutrition and Exercise Physiology
Washington State University